Organization of pERK-immunoreactive cells in trigeminal spinal nucleus caudalis and upper cervical cord following capsaicin injection into oral and craniofacial regions in rats

The Journal of Comparative Neurology
Noboru NomaKoichi Iwata

Abstract

To define the somatotopic arrangement of neurons in the trigeminal spinal subnucleus caudalis and upper cervical cord activated by acute noxious stimulation of various orofacial sites, pERK expression was analyzed in these neurons. After capsaicin injection into the tongue, lower gum, upper and lower lips, or mental region, pERK-like immunoreactive (pERK-LI) cells were distributed mainly in the dorsal half of the trigeminal spinal nucleus interporalis (Vi) and caudalis (Vc) transition zone (Vi/Vc zone), middle Vc, and Vc and upper cervical cord transition zone (Vc/C2 zone). pERK-LI cells were distributed throughout the dorsal to ventral portion of the Vi/Vc zone, middle Vc, and Vc/C2 zone following capsaicin injection into the anterior hard palate, upper gum, buccal mucosa, or vibrissal pad and in the ventral portion of the Vi/Vc zone, middle Vc, and Vc/C2 zone following snout, ophthalmic, or ocular injection of capsaicin. The rostrocaudal distribution area of pERK-LI cells was more extensive from the Vi/Vc zone to the Vc/C2 zone after intraoral injection than that after facial injection, and the rostrocaudal distribution of pERK-LI cells from the Vi/Vc zone to the Vc/C2 zone had a somatotopic arrangement, with the snout being ...Continue Reading

References

Oct 8, 1991·The Journal of Comparative Neurology·E Bullitt
Jan 1, 1991·Lasers in Surgery and Medicine·P SvenssonS Kaaber
Jul 1, 1988·The Journal of Physiology·F Cervero, K A Sharkey
Jan 15, 1986·The Journal of Comparative Neurology·Y ShigenagaM Hosoi
Jan 1, 1983·Annual Review of Neuroscience·R Dubner, G J Bennett
Nov 24, 1999·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·B J Sessle
Dec 3, 2003·Journal of Oral Rehabilitation·T OgawaK Koyano

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Citations

Sep 10, 2009·Brain : a Journal of Neurology·Marie-Luise SixtMichael J M Fischer
Dec 23, 2011·Development·Y Albert PanAlexander F Schier
Sep 11, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Akiko Okada-OgawaKoichi Iwata
Jan 7, 2009·The Journal of Physiology·Takanori TsujimuraKoichi Iwata
May 7, 2013·The Journal of Pain : Official Journal of the American Pain Society·Ye CaoBarry J Sessle
Apr 29, 2009·The Journal of Pain : Official Journal of the American Pain Society·Emi ShodaKoichi Iwata
Oct 5, 2010·The Journal of Comparative Neurology·Verena C WimmerRandy M Bruno
Mar 4, 2014·The European Journal of Neuroscience·Laura FrangeulDenis Jabaudon
May 14, 2014·British Journal of Pharmacology·Roshni Ramachandran, Tony L Yaksh
May 11, 2015·Neurobiology of Disease·Roshni RamachandranTony L Yaksh
Nov 29, 2014·Neurochemical Research·Ryuji TerayamaTomosada Sugimoto
Sep 29, 2012·Journal of Dental Research·M HasegawaK Iwata
Jan 24, 2013·Journal of Dental Research·K MurasakiK Tanne
Dec 28, 2018·Journal of Oral Science·Tatsuro SuzukiKoichi Iwata
Sep 29, 2020·Molecular Pain·Mamoru ShibataJin Nakahara
May 9, 2019·Journal of Dental Anesthesia and Pain Medicine·Koichi Iwata, Masamichi Shinoda
Sep 19, 2017·The International Journal of Neuroscience·Mitsuyasu TabataTomosada Sugimoto
May 22, 2020·Oral Diseases·Qing LiuFang Huang

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