PMID: 9194065May 1, 1997Paper

Organization of the Drosophila genome in mutants with changes in second messenger metabolism and learning ability

Neuroscience and Behavioral Physiology
A V MedvedevaV S Kornitskiĭ

Abstract

Mechanisms modifying the structural-functional organization of polytene chromosomes were studied in a Drosophila line in which the activating properties of calmodulin were altered and learning ability was increased, by treating mutants with homeopathic preparations which affect Ca2+ and F- ion metabolism. The results indicated a dominant role for Ca2+ ions and calmodulin in determining the chromocentric organization of the nucleus. F- ions, which stimulate the adenylate cyclase complex, were found not to have a role.

References

Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J W Jack, B H Judd

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