Organization of the equine immunoglobulin constant heavy chain genes. I. c epsilon and c alpha genes

Veterinary Immunology and Immunopathology
Bettina WagnerAndreas Radbruch

Abstract

We provide a restriction map of the equine c epsilon and c alpha genes as a molecular basis for isotype classification. Human and murine DNA probes were used for identification of homologous equine DNA sequences and for isolation of the equine c epsilon and c alpha genes from a genomic DNA library. A detailed map of the equine 5'-s epsilon/c epsilon-s alpha/c alpha-3' gene region was obtained. Equine c epsilon and c alpha DNA probes were prepared and used for restriction analysis of immunoglobulin heavy chain gene loci from different horses. This analysis indicated the presence of only one equine c epsilon and one c alpha gene in the haploid equine genome. In addition, for the equine c alpha gene, four haplotypes were identified according to BamHI restriction fragment length polymorphism (RFLP) of genomic DNA. The relative location of the c epsilon and c alpha genes 3' of the equine c mu and c gamma genes was determined by restriction analysis of equi-murine heterohybridomas.

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Citations

Oct 6, 2001·Veterinary Immunology and Immunopathology·B WagnerW Leibold
Feb 15, 2003·Veterinary Immunology and Immunopathology·Eliane MartiD Paul Lunn
Mar 12, 2003·Veterinary Immunology and Immunopathology·Bettina WagnerWolfgang Leibold
Jan 8, 1999·Veterinary Immunology and Immunopathology·G OvereschW Leibold
Jul 10, 2002·Trends in Immunology·Falko SteinbachBettina Wagner
Oct 13, 2009·Veterinary Immunology and Immunopathology·Bettina Wagner
Jul 28, 2005·Developmental and Comparative Immunology·Bettina Wagner
Aug 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bettina WagnerDouglas F Antczak
Nov 4, 2004·Seminars in Immunology·Janet Stavnezer, Chris T Amemiya

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