Organization of the hamster intergeniculate leaflet: NPY and ENK projections to the suprachiasmatic nucleus, intergeniculate leaflet and posterior limitans nucleus

Visual Neuroscience
Lawrence P Morin, J Blanchard

Abstract

The intergeniculate leaflet (IGL) is an integral part of the circadian visual system. It receives direct retinal input and relays photic information to the circadian clock in the suprachiasmatic nucleus (SCN) through a geniculohypothalamic tract (GHT). In both rat and hamster, neuropeptide Y immunoreactive (NPY-IR) IGL cells project through the GHT to the SCN. However, the hamster GHT also contains enkephalin-IR (ENK-IR) fibers, presumably of IGL origin. In the present investigations, the IGL was examined for NPY-, ENK-, or dual-IR cells. Their projections to the SCN, contralateral IGL and pretectum were also studied. The results show that the hamster IGL contains both NPY- and ENK-IR neurons and that about 50% of these are immunoreactive to both peptides. Double-label retrograde analysis indicates that cells of each peptide class project to the SCN. Similarly, IGL neurons, many of which are NPY- and ENK-IR, project to the pretectum, particularly the posterior limitans nucleus. While numerous IGL neurons project contralaterally, very few are NPY- or ENK-IR. The distribution of SCN- and pretectum-projecting cells, in conjunction with the distribution of peptide-IR neurons, allows expansion of the IGL definition to include the re...Continue Reading

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Citations

May 30, 2001·Brain Research·E G Marchant, L P Morin
Feb 17, 2006·Journal of Circadian Rhythms·Vallath Reghunandanan, Rajalaxmy Reghunandanan
Apr 26, 2012·Journal of Chemical Neuroanatomy·Ruthnaldo R M LimaJeferson S Cavalcante
Jul 30, 2003·Brain Research·Rebecca C Tischler, L P Morin
Dec 13, 2005·Brain Research Reviews·L P Morin, C N Allen
Aug 21, 2003·Neuroscience·G S Lall, S M Biello
Aug 27, 2016·Frontiers in Neuroanatomy·Emmanuel Márquez-LegorretaEnrique Saldaña
Nov 7, 1998·Journal of Sex & Marital Therapy·J L Silverstein
Feb 22, 2017·The Journal of Physiology·Lydia HannaTimothy M Brown
Oct 21, 2003·The Journal of Comparative Neurology·Louise MuscatLawrence P Morin
Jan 17, 2013·The Journal of Comparative Neurology·Frédéric GaillardYves Sauvé
Jun 1, 2006·The Journal of Comparative Neurology·Samer HattarDavid M Berson
May 10, 2005·The Journal of Comparative Neurology·Lawrence P Morin, Jane H Blanchard
Apr 29, 1999·Annals of Medicine·L P Morin

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