PMID: 12782134Jun 5, 2003Paper

Organization of the human FK506-binding immunophilin FKBP52 protein gene (FKBP4)

Genomics
Jonathan G ScammellDonna L Valentine

Abstract

FKBP52 is a widely expressed FK506-binding immunophilin that possesses peptidylprolyl isomerase activity and a tetratricopeptide repeat involved in protein-protein interaction. FKBP52 plays an important role in steroid receptor function and is implicated in other diverse processes, including regulation of transcription, cation channel activity, and gene transfer efficiency. Reported here is the genomic organization of the human FKBP52 gene (FKBP4), which shares all but one of the same exon-intron boundaries as the structurally related immunophilin FKBP51 gene (FKBP5). Approximately 3.5 kb of 5'-flanking DNA of FKBP4 was subcloned into a luciferase reporter vector and was found to exhibit robust activity in T-47D, MCF7, and COS-7 cells. Promoter constructs with only 143 bp of upstream sequence maintained high activity. This region contains a CAAT motif sequence and consensus binding sites for Sp1, heat-shock factor, and MYC-MAX, which are conserved in the rabbit FKBP4 promoter and, when deleted, dramatically reduced promoter activity in T-47D cells.

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Citations

Mar 11, 2004·Journal of Molecular and Cellular Cardiology·Y JamshidiD S Latchman
Apr 12, 2013·Journal of the American Chemical Society·Ting-Chun HungChi-Huey Wong
Oct 23, 2004·Cell Stress & Chaperones·David F Smith
Nov 17, 2004·Cell Stress & Chaperones·Tina R Hubler, Jonathan G Scammell
May 28, 2010·Pharmacogenomics·David BrentGustavo Turecki
Apr 26, 2011·Current Opinion in Pharmacology·Donna L CioffiJonathan G Scammell
May 3, 2012·Journal of Neurochemistry·Natalia M GalignianaMario D Galigniana
Sep 12, 2015·Gene·Michael Haase, Guido Fitze
Oct 10, 2015·Adipocyte·Judith ToneattoGraciela Piwien-Pilipuk
Nov 9, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Guoping CaoWenjun Fu
Apr 8, 2004·Physiological Genomics·Jean F ChallacombeThomas S Brettin
Sep 11, 2019·Human Molecular Genetics·Charalambos DemetriouGudrun E Moore

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