Organization of the Influenza A Virus Genomic RNA in the Viral Replication Cycle-Structure, Interactions, and Implications for the Emergence of New Strains

Pathogens
Julita PiaseckaElzbieta Kierzek

Abstract

The influenza A virus is a human pathogen causing respiratory infections. The ability of this virus to trigger seasonal epidemics and sporadic pandemics is a result of its high genetic variability, leading to the ineffectiveness of vaccinations and current therapies. The source of this variability is the accumulation of mutations in viral genes and reassortment enabled by its segmented genome. The latter process can induce major changes and the production of new strains with pandemic potential. However, not all genetic combinations are tolerated and lead to the assembly of complete infectious virions. Reports have shown that viral RNA segments co-segregate in particular circumstances. This tendency is a consequence of the complex and selective genome packaging process, which takes place in the final stages of the viral replication cycle. It has been shown that genome packaging is governed by RNA-RNA interactions. Intersegment contacts create a network, characterized by the presence of common and strain-specific interaction sites. Recent studies have revealed certain RNA regions, and conserved secondary structure motifs within them, which may play functional roles in virion assembly. Growing knowledge on RNA structure and intera...Continue Reading

References

Feb 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yutaka FujiiYoshihiro Kawaoka
Jul 30, 2005·Journal of Virology·Yuying LiangTristram G Parslow
Jan 27, 2006·Nature·Takeshi NodaYoshihiro Kawaoka
Dec 6, 2006·Proceedings of the National Academy of Sciences of the United States of America·Audray HarrisAlasdair C Steven
Mar 3, 2007·Nucleic Acids Research·Julia R GogPaul Digard
May 25, 2007·Molecular Biology and Evolution·Lone SimonsenEdward C Holmes
May 7, 2008·Comparative Immunology, Microbiology and Infectious Diseases·Chang-Won Lee, Yehia M Saif
Sep 26, 2008·Journal of Virology·Edward C HutchinsonPaul Digard
Jun 27, 2009·PLoS Pathogens·Rocío ColomaJaime Martín-Benito
Dec 4, 2009·The Journal of General Virology·Edward C HutchinsonPaul Digard
Jan 12, 2010·Current Opinion in Structural Biology·Rob W H RuigrokStephen Cusack
Aug 31, 2010·PLoS Currents·Corinne BergeronMichele Ottmann
Oct 7, 2010·International Reviews of Immunology·Alexander P GultyaevRené C L Olsthoorn
May 11, 2011·The Journal of Biological Chemistry·Erin NobleBaek Kim
Nov 15, 2011·Nucleic Acids Research·Emilie FournierRoland Marquet
Jan 26, 2012·Nature Communications·Takeshi NodaYoshihiro Kawaoka
Feb 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Benjamin D GreenbaumRaul Rabadan
Nov 28, 2012·Science·Rocío ArranzJaime Martín-Benito
Jan 4, 2013·Journal of Virology·Christopher B BrookeJonathan W Yewdell
Sep 18, 2013·Proceedings of the National Academy of Sciences of the United States of America·Boris EssereVincent Moules
Sep 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Cyrille GavazziRoland Marquet
Jul 11, 2014·Journal of Virology·Steven F BakerLuis Martínez-Sobrido
Sep 3, 2014·RNA Biology·Alexander P GultyaevRené C L Olsthoorn
Sep 17, 2014·Nature Communications·Edward C HutchinsonErvin Fodor
Nov 20, 2014·Nature·Alexander PflugStephen Cusack
Nov 25, 2014·Nature Reviews. Microbiology·Amie J EisfeldYoshihiro Kawaoka
Nov 26, 2015·Vaccine·Leslie A ReperantAlbert D M E Osterhaus
Feb 6, 2016·PloS One·Elzbieta LenartowiczElzbieta Kierzek

❮ Previous
Next ❯

Citations

Jun 3, 2021·International Journal of Molecular Sciences·Ludmila V PuchkovaEkaterina Yu Ilyechova

❮ Previous
Next ❯

Methods Mentioned

BETA
antisense oligonucleotides
SHAPE-MaP
immunoprecipitation
crosslinking immunoprecipitation
HITS-CLIP
PAR-CLIP
SPLASH
electrophoretic mobility shift assay
electron tomography
transfection

Software Mentioned

SPLASH
CLIP
PAR

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.