Organization of the lipoprotein lipase gene of red sea bream Pagrus major

Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
Hiromi OkuXu-Fang Liang

Abstract

Lipoprotein lipase (LPL) is a key enzyme of lipid deposition and metabolism. To investigate the mechanism of lipid deposition in fish, as a first step, we have characterized the LPL gene of a marine teleost red sea bream Pagrus major by cDNA and genomic structure analysis. The red sea bream LPL gene encodes 511 amino acids and spans approximately 6.3 kb of the genome. The coding region is organized into ten exons and nine introns. In comparison with the LPL of other animals, the deduced amino acid sequence shows a high degree of similarity with a conservation of functional domains, e.g. catalytic triad, N-glycosylation sites, lipid and heparin binding regions. The 1.1 kb of 5' flanking region contains two CCAAT, sequences homologous to Oct-I site and response elements for hormones including glucocorticoid, insulin and thyroid hormone. The results of the present study will facilitate further study of the function and regulation of the LPL in non-mammalian vertebrates.

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Citations

Feb 25, 2009·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Han-liang ChengXiao-yun Shi
Dec 27, 2006·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Alfonso Saera-VilaJaume Pérez-Sánchez
May 24, 2006·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Hiromi OkuTetsuya Umino
Apr 22, 2015·Fish Physiology and Biochemistry·Pin LiuPing Yu
Feb 7, 2006·General and Comparative Endocrinology·Amaya AlbalatIsabel Navarro
Jun 30, 2007·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·A AlbalatI Navarro
Aug 24, 2005·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Alfonso Saera-VilaJaume Pérez-Sánchez
Aug 12, 2008·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Hiromi Oku, Tetsuya Umino

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