Organization of TNIK in dendritic spines

The Journal of Comparative Neurology
Alain C BuretteR J Weinberg

Abstract

Tumor necrosis factor receptor-associated factor 2 (TRAF2)- and noncatalytic region of tyrosine kinase (NCK)-interacting kinase (TNIK) has been identified as an interactor in the psychiatric risk factor, Disrupted in Schizophrenia 1 (DISC1). As a step toward deciphering its function in the brain, we performed high-resolution light and electron microscopic immunocytochemistry. We demonstrate here that TNIK is expressed in neurons throughout the adult mouse brain. In striatum and cerebral cortex, TNIK concentrates in dendritic spines, especially in the vicinity of the lateral edge of the synapse. Thus, TNIK is highly enriched at a microdomain critical for glutamatergic signaling.

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Citations

Dec 10, 2015·The Journal of Pharmacology and Experimental Therapeutics·Qi WangMichael D Ehlers
Apr 24, 2016·Human Genetics·Shams AnaziFowzan S Alkuraya
Jul 17, 2018·The Journal of Physiology·Daniela TropeaKevin Fox
Jun 3, 2021·Journal of Neurochemistry·Alicyia Walczyk-MooradallyJasmin Lalonde

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