Organization of visual mossy fiber projections and zebrin expression in the pigeon vestibulocerebellum

The Journal of Comparative Neurology
Janelle M P PakanDouglas R W Wylie

Abstract

Extensive research has revealed a fundamental organization of the cerebellum consisting of functional parasagittal zones. This compartmentalization has been well documented with respect to physiology, biochemical markers, and climbing fiber afferents. Less is known about the organization of mossy fiber afferents in general, and more specifically in relation to molecular markers such as zebrin. Zebrin is expressed by Purkinje cells that are distributed as a parasagittal array of immunopositive and immunonegative stripes. We examined the concordance of zebrin expression with visual mossy fiber afferents in the vestibulocerebellum (folium IXcd) of pigeons. Visual afferents project directly to folium IXcd as mossy fibers and indirectly as climbing fibers via the inferior olive. These projections arise from two retinal recipient nuclei: the lentiformis mesencephali (LM) and the nucleus of the basal optic root (nBOR). Although it has been shown that these two nuclei project to folium IXcd, the detailed organization of these projections has not been reported. We injected anterograde tracers into LM and nBOR to investigate the organization of mossy fiber terminals and subsequently related this organization to the zebrin antigenic map. ...Continue Reading

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Citations

Mar 10, 2011·Brain Structure & Function·Stacey L ReeberRoy V Sillitoe
Aug 13, 2013·Journal of Chemical Neuroanatomy·Douglas R WylieAndrew N Iwaniuk
Mar 4, 2014·PloS One·Jerry SkefosMargaret Bauman
Apr 18, 2012·Journal of Visualized Experiments : JoVE·Joshua J WhiteRoy V Sillitoe
Nov 23, 2011·The Journal of Comparative Neurology·Douglas R WylieAndrew N Iwaniuk
Aug 7, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·E A GilbertC L Armstrong
May 16, 2014·The Journal of Comparative Neurology·Janelle M P PakanDouglas R Wylie
Jan 21, 2015·Nature Reviews. Neuroscience·Nadia L CerminaraRichard Apps
Aug 22, 2014·PloS One·Jianqiang XiaoEric J Lang
Dec 15, 2015·The Journal of Comparative Neurology·Tomas Vega-ZunigaHarald Luksch
Jan 18, 2018·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Cristian Gutierrez-IbanezDouglas R Wylie
Nov 26, 2010·Brain, Behavior and Evolution·Masato FurueMasato Uehara
Jul 22, 2014·The Journal of Comparative Neurology·Douglas R WylieCristian Gutierrez-Ibanez
Apr 25, 2018·Frontiers in Neuroscience·Douglas R WylieAndrew N Iwaniuk
Sep 30, 2021·The Journal of Comparative Neurology·Cristian Gutiérrez-IbáñezDouglas R Wylie
Mar 11, 2020·Brain, Behavior and Evolution·Cristián Gutiérrez-IbáñezDouglas R Wylie

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