Organization versus activation: the role of endocrine-disrupting contaminants (EDCs) during embryonic development in wildlife

Environmental Health Perspectives
L J GuilletteD B Pickford

Abstract

Many environmental contaminants disrupt the vertebrate endocrine system. Although they may be no more sensitive to endocrine-disrupting contaminants (EDCs) than other vertebrates, reptiles are good sentinels of exposure to EDCs due to the lability in their sex determination. This is exemplified by a study of alligators at Lake Apopka, Florida, showing that EDCs have altered the balance of reproductive hormones resulting in reproductive dysfunction. Such alterations may be activationally or organizationally induced. Much research emphasizes the former, but a complete understanding of the influence of EDCs in nature can be generated only after consideration of both activational and organizational alterations. The organizational model suggests that a small quantity of an EDC, administered during a specific period of embryonic development, can permanently modify the organization of the reproductive, immune, and nervous systems. Additionally, this model helps explain evolutionary adaptations to naturally occurring estrogenic compounds, such as phytoestrogens.

References

Mar 1, 1978·Cancer Letters·T Kalland, J G Forsberg
Apr 1, 1992·General and Comparative Endocrinology·V A Lance, M H Bogart
Apr 1, 1992·Proceedings of the Society for Experimental Biology and Medicine·T MoriH A Bern
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·L ScavoF de Pablo
Jan 1, 1991·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·N SinhaT P Singh
Dec 1, 1991·The Journal of Endocrinology·J F Tait, S A Tait
Jun 1, 1991·The Quarterly Review of Biology·F J Janzen, G L Paukstis
Mar 1, 1991·General and Comparative Endocrinology·D CrewsT Wibbels
Nov 1, 1990·Proceedings of the Society for Experimental Biology and Medicine·F D UchimaH A Bern
Feb 1, 1989·Endocrine Reviews·A BatemanS Solomon
Aug 15, 1989·Biochemical and Biophysical Research Communications·L ScavoF de Pablo
Dec 1, 1988·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D C Deeming, M W Ferguson
Nov 1, 1987·Bulletin of Environmental Contamination and Toxicology·A M BryanP G Olafsson
Jun 1, 1988·General and Comparative Endocrinology·J J BullD Crews
Dec 1, 1986·General and Comparative Endocrinology·W H Gutzke, J J Bull
Dec 1, 1985·Hormones and Behavior·A P Arnold, S M Breedlove
Jan 1, 1981·International Journal of Nuclear Medicine and Biology·E R Farre, Y Cohen
Aug 21, 1981·Science·D M Fry, C K Toone
May 1, 1995·Environmental Health Perspectives·L J GuilletteH F Percival
Jan 1, 1995·Proceedings of the Society for Experimental Biology and Medicine·J R LevyC L Hughes
Oct 1, 1993·Environmental Health Perspectives·T ColbornA M Soto
Oct 1, 1993·Environmental Health Perspectives·J A McLachlan
Feb 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·H AdlercreutzL E Vickery
Sep 1, 1994·Environmental Health Perspectives·J M BergeronJ A McLachlan
Oct 1, 1964·British Journal of Industrial Medicine·D F HEATH, M VANDEKAR
Nov 1, 1946·The British Veterinary Journal·H W BENNETTSF L SHIER
Feb 1, 1946·Australian Veterinary Journal·H W BENNETTSF L SHIER
Mar 1, 1991·Environmental Monitoring and Assessment·G H HeinzM L Jennings

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Citations

Sep 11, 2007·Bioscience, Biotechnology, and Biochemistry·Masao GotoHiroshi Shinmoto
Dec 22, 1999·General and Comparative Endocrinology·L J GuilletteH F Percival
Dec 6, 2008·Environmental Health Perspectives·Krista A McCoyColette M St Mary
Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M Betka, G V Callard
Jan 1, 1996·Archives of Environmental Health·J D Sherman
Nov 25, 1998·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·M FingermanR Nagabhushanam
Oct 16, 2004·Ecotoxicology and Environmental Safety·Sébastien Sauvé, Michel Fournier
Dec 31, 2002·Toxicology·Louis J GuilletteJohn A McLachlan
May 5, 2010·Bulletin of Environmental Contamination and Toxicology·Jeong Hwan OhEun Sang Choe
Apr 15, 2008·Trends in Endocrinology and Metabolism : TEM·N Ben-Jonathan, R Steinmetz
Dec 4, 2003·General and Comparative Endocrinology·Andrew A RooneyLouis J Guillette
Jan 14, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Karin KinnbergPoul Bjerregaard
Jul 21, 2011·Drug and Chemical Toxicology·Chun-Chi KuoChung-Ren Jan
Aug 14, 2002·Drug and Chemical Toxicology·Douglas J FortBrody O Buzzard
Apr 24, 2012·Toxicology and Applied Pharmacology·Angelo VedaniMartin Smieško
Mar 5, 2016·Bulletin of Environmental Contamination and Toxicology·Jonathan M AliAlan S Kolok
Jul 21, 2009·The Journal of Steroid Biochemistry and Molecular Biology·M M EsterhuyseJ H van Wyk
Mar 20, 2008·Fertility and Sterility·Louis J Guillette, Thea M Edwards
Apr 5, 2008·The Science of the Total Environment·Yan-Rang WangXue-Ying Yang
Jul 3, 2007·Reproductive Toxicology·D Andrew CrainLouis J Guillette
Oct 7, 2015·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Jamie L YoungJohn Pierce Wise
Mar 26, 2003·Journal of Morphology·Andrew A RooneyLouis J Guillette
Aug 26, 2006·Basic & Clinical Pharmacology & Toxicology·Angelo VedaniMarkus A Lill
Jun 16, 2000·Environmental Health Perspectives·S H Safe
May 3, 2001·Environmental Health Perspectives·A C Melo, J S Ramsdell
Mar 4, 2005·Environmental Health Perspectives·Vance L TrudeauBarbara Demeneix
Mar 4, 2005·Environmental Health Perspectives·Amy L ReederVal R Beasley
Nov 20, 2013·Environmental Toxicology and Chemistry·Daniel C RearickHeiko L Schoenfuss
Aug 18, 2004·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Matthew R MilnesLouis J Guillette

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