PMID: 9551723Apr 29, 1998Paper

Organizing pneumonia in textile printing workers: a clinical description

The European Respiratory Journal
S RomeroJ Sanchez-Payá

Abstract

In April 1992 an outbreak of severe respiratory illness occurred among aerographic textile workers in the area of Alcoi, Autonomous Community of Valencia, Spain. An epidemiological study linked this outbreak to the use of a reformulated aerosolized product, Acramin-FWN. We analyzed clinical, laboratory, and pathological data of the first 14 patients with confirmed organizing pneumonia (OP) secondary to this newly recognized occupational toxicant. The mean age of the patients was 30 yrs. The most common clinical findings were cough (86%), epistaxis (71%), dyspnoea (64%), oppressive chest pain (57%), and crackles (50%). A restrictive functional pattern was evident in 64%. Radiographic findings consisted predominantly of patchy infiltrates in 65% and a micronodular pattern in 35%. Treatment with corticosteroids did not prevent initial progression in 11 of the 14 patients and development of irreversible respiratory failure in five patients. At necropsy, besides features of OP, interstitial fibrosis and diffuse alveolar damage were evident. A low total lung capacity, the presence of crackles at admission, and increases in the alveolar-arterial oxygen difference were predictive of death. The organizing pneumonia caused by the inhalat...Continue Reading

Citations

Aug 2, 2002·The New England Journal of Medicine·E Neil Schachter
Mar 31, 2000·Current Opinion in Pulmonary Medicine·P De Vuyst, P Camus
Mar 18, 2000·Thorax·J F Cordier
Jan 25, 2012·Journal of Toxicologic Pathology·Toshinori YoshidaTakanori Harada
Dec 24, 2009·AJR. American Journal of Roentgenology·Lucía FlorsJosé Vilar
May 24, 2014·European Journal of Radiology·Masanori Akira, Narufumi Suganuma
Feb 27, 2014·Radiology·Christian W CoxDavid A Lynch
Mar 17, 2006·Allergologia et immunopathologia·I Reig Rincón de ArellanoC Martínez-Cócera
Aug 28, 2004·Clinics in Chest Medicine·Craig S Glazer, Lee S Newman
Apr 12, 2017·Annals of the American Thoracic Society·Romain PersichiniNathalie Coolen-Allou
Jan 5, 2002·Critical Reviews in Toxicology·D B WarheitG L Kennedy
May 31, 2007·Respiration; International Review of Thoracic Diseases·Encarnacion BarrosoSantiago Romero
Jun 1, 2019·American Journal of Respiratory and Critical Care Medicine·Paul D BlancCarrie A Redlich
Sep 6, 2005·Revue de pneumologie clinique·Romain Lazor

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