Abstract
Researchers and health officials are increasingly using electronic linkage of large-scale health data systems as a tool for assembling a comprehensive picture of birth defects at a population level. Current linkage and database techniques are limited to first-order linkage--linking information on a single individual in one database with information on that same individual in another database. For example, while current strategies may indicate whether a child with a certain birth defect also has a specific metabolic disorder or risk factor, they are unable to readily determine whether he or she also has any siblings or other relatives with the same pattern. In contrast, the current manuscript proposes a second-order linkage--one that organizes data so that individual-level data can readily be organized into families or extended family pedigrees across an entire population. The ability to link and organize population data into family pedigrees can have significant, broad impact upon health research and service delivery. This can lead to large-scale analysis of genetic factors and, with the linking of environmental data, the potential for large-scale studies of gene-environment interactions. In addition, it expands the potential f...Continue Reading
References
Nov 2, 1994·Journal of the National Cancer Institute·D E GoldgarM H Skolnick
Jun 10, 1998·Paediatric and Perinatal Epidemiology·R Byron-ScottK Clark
Nov 11, 1999·Human Molecular Genetics·S L NeuhausenL A Cannon-Albright
Mar 7, 2000·Paediatric and Perinatal Epidemiology·M B Forrester, R D Merz
Sep 19, 2000·Teratology·M R AranetaG C Gray
Sep 21, 2000·American Journal of Epidemiology·K BromenK H Jöckel
Mar 22, 2001·The New England Journal of Medicine·M S EsplinM W Varner
Jan 5, 2002·American Journal of Epidemiology·Beate RitzJohn A Harris
Jan 5, 2002·The New England Journal of Medicine·Rolv SkjaervenRolv T Lie
Jan 24, 2002·Human Biology·I Rudan
Feb 2, 2002·Journal of Epidemiology and Biostatistics·K M Boucher, R A Kerber
Feb 22, 2002·Paediatric and Perinatal Epidemiology·Kari Klungsøyr MelveNina Øyen
May 8, 2002·American Journal of Epidemiology·Kari Klungsøyr Melve, Rolv Skjaerven
Mar 29, 2003·Genetics·Igor RudanPavao Rudan
Aug 13, 2003·International Journal of Epidemiology·Kari Klungsøyr Melve, Rolv Skjaerven