Organizing principles for the cerebral cortex network of commissural and association connections

Proceedings of the National Academy of Sciences of the United States of America
Larry W SwansonOlaf Sporns

Abstract

Cognition is supported by a network of axonal connections between gray matter regions within and between right and left cerebral cortex. Global organizing principles of this circuitry were examined with network analysis tools applied to monosynaptic association (within one side) and commissural (between sides) connections between all 77 cortical gray matter regions in each hemisphere of the rat brain. The analysis used 32,350 connection reports expertly collated from published pathway tracing experiments, and 5,394 connections of a possible 23,562 were identified, for a connection density of 23%-of which 20% (1,084) were commissural. Network community detection yielded a stable bihemispheric six-module solution, with an identical set in each hemisphere of three modules topographically forming a lateral core and medial shell arrangement of cortical regions. Functional correlations suggest the lateral module deals preferentially with environmental sensory-motor interactions and the ventromedial module deals preferentially with visceral control, affect, and short-term memory, whereas the dorsomedial module resembles the default mode network. Analysis of commissural connections revealed a set of unexpected rules to help generate hy...Continue Reading

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Citations

Mar 30, 2019·Proceedings of the National Academy of Sciences of the United States of America·Joel D HahnLarry W Swanson
Nov 2, 2019·Nature·Julie A HarrisHongkui Zeng
Sep 6, 2018·Proceedings of the National Academy of Sciences of the United States of America·Rodrigo SuárezLinda J Richards
Jun 20, 2019·Proceedings of the National Academy of Sciences of the United States of America·Larry W SwansonJoel D Hahn
May 6, 2020·Brain Structure & Function·Alexander WoodwardNoritaka Ichinohe
Jul 4, 2018·Proceedings of the National Academy of Sciences of the United States of America·Larry W SwansonOlaf Sporns
Jan 16, 2019·Cold Spring Harbor Symposia on Quantitative Biology·Scott A Small, Larry W Swanson
Dec 7, 2019·Proceedings of the National Academy of Sciences of the United States of America·Larry W SwansonJoel D Hahn
Nov 25, 2019·Brain Structure & Function·Joshua Faskowitz, Olaf Sporns
Nov 25, 2020·Proceedings of the National Academy of Sciences of the United States of America·Larry W SwansonOlaf Sporns
Jul 2, 2020·NeuroImage·Yikang LiuNanyin Zhang
May 14, 2021·Proceedings of the National Academy of Sciences of the United States of America·Larry W SwansonOlaf Sporns
Jul 22, 2021·Nature Reviews. Neurology·Meichen YuAndrew J Saykin

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