Organocatalytic Asymmetric Annulation between Hydroxymaleimides and Nitrosoarenes: Stereoselective Preparation of Chiral Quaternary N-Hydroxyindolines

Organic Letters
Yu YangLi-Xin Wang

Abstract

An unusual and highly effective asymmetric annulation of nitrosoarenes with hydroxymaleimides catalyzed by a chiral bifunctional amine squaramide catalyst has been disclosed. A wide range of highly fused chiral N-hydroxyindolines with two consecutive quaternary stereocenters and multifunctional groups were directly and effectively prepared in excellent yields (up to >99%) with complete regioselective cyclization and excellent stereoselectivities (up to >99:1 dr and >99% ee). The efficiency and potentials of the new reaction and the target chiral entities were well demonstrated by delicate transformations into a series of new chiral indolines.

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Citations

Nov 23, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Khidmet ShikhalievKristina Yankina
Feb 13, 2018·Chemistry, an Asian Journal·DingXi LiJaesook Yun

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