Organocatalytic asymmetric formal [4 + 2] cycloaddition for the synthesis of spiro[4-cyclohexanone-1,3'-oxindoline] derivatives in high optical purity

Organic Letters
Qiang Wei, Liu-Zhu Gong

Abstract

A bifunctional organocatalytic asymmetric formal [4 + 2] cycloaddition reaction of Nazarov reagents and methyleneindolinones afforded spiro[4-cyclohexanone-1,3'-oxindoline] derivatives with excellent enantioselectivity (up to 98% ee).

References

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Sep 10, 2009·Journal of the American Chemical Society·Xiao-Hua ChenLiu-Zhu Gong

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Citations

May 28, 2011·Chemical Reviews·Albert Moyano, Ramon Rios
Sep 7, 2012·Chemical Reviews·Girija S Singh, Zelalem Y Desta
Aug 24, 2010·Chemical Communications : Chem Comm·Xavier CompanyóRamon Rios
May 31, 2011·Chemical Communications : Chem Comm·Vijay P SinghRay J Butcher
Oct 8, 2016·Organic & Biomolecular Chemistry·Juanjuan WangYing Fu
Aug 15, 2012·Chemistry : a European Journal·Hongxin LiuJun Jiang
Feb 22, 2013·Chemistry : a European Journal·Huicai HuangJinxing Ye
Sep 21, 2010·Chemistry : a European Journal·Arnaud VoituriezAngela Marinetti
Jan 13, 2012·Organic & Biomolecular Chemistry·Andrea MazzantiRamon Rios
Mar 1, 2012·Organic & Biomolecular Chemistry·Hosamani Basavaprabhu, Vommina V Sureshbabu
May 15, 2012·Organic & Biomolecular Chemistry·Nicolas R Ball-JonesAnnaliese K Franz
Oct 12, 2013·Chemistry : a European Journal·Ulf Scheffler, Rainer Mahrwald
Dec 4, 2013·Organic & Biomolecular Chemistry·Dhevalapally B RamacharyR Madhavachary
May 21, 2014·Organic & Biomolecular Chemistry·Xiao-Fei HuangXing-Wang Wang

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