PMID: 28525722DOI: 10.1021/acs.joc.7b00363May 20, 2017Paper
Organocatalytic Asymmetric Michael-Hemiacetalization Reaction Between 2-Hydroxyacetophenones and Enals: A Route to Chiral β,γ-Disubstituted γ-Butyrolactones
The Journal of Organic Chemistry
Megha BalhaSubhas Chandra Pan
Abstract
The first highly enantioselective organocatalytic reaction employing 2-hydroxyacetophenones is disclosed, namely Michael-hemiacetalization reaction of 2-hydroxyacetophenones with enals. The combination of a primary amine and a secondary amine catalyst was found to be the best choice for this methodology. The products of this reaction were obtained in high enantio- and diastereoselectivities and were converted to a variety of biologically important γ-butyrolactones.
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Jul 17, 2019·Organic & Biomolecular Chemistry·Yu-Hang MiaoMin-Can Wang
May 31, 2019·The Journal of Organic Chemistry·Xiao-Chao YangMin-Can Wang
Dec 13, 2019·The Journal of Organic Chemistry·Sha HuFener Chen
Jul 20, 2019·Organic Letters·Pratibha MahtoVinod K Singh
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