Organochlorine compounds in relation to breast cancer, endometrial cancer, and endometriosis: an assessment of the biological and epidemiological evidence

Critical Reviews in Toxicology
U AhlborgH O Adami

Abstract

There is an increasing public and scientific concern that certain chlorinated compounds, recognized as environmental pollutants, may cause estrogen-related neoplastic disease in humans. The main hypothesis has been that certain organochlorines, through their estrogenic actions, might cause breast cancer. From experimental studies, both in vitro and in vivo, there is evidence that certain organochlorine compounds may cause estrogenic effects, whereas others may cause antiestrogenic effects. In limited studies, some of these compounds in high doses have also been shown to increase and reduce the frequency of estrogen-related tumors in animals. The epidemiological findings regarding the association between organochlorines and breast cancer are inconclusive. However, the largest and best designed study has been interpreted as negative with respect to DDT and polychlorinated biphenyls (PCB) in relation to breast cancer. Associations between organochlorine exposure and endometrial cancer or endometriosis have even more limited empirical basis. The hypothesis that human exposure to environmental levels or organochlorines would favor an estrogenic overactivity leading to an increase in estrogen-dependent formation of mammary or endomet...Continue Reading

References

Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·B HammondJ McConnell
Sep 1, 1978·Ecotoxicology and Environmental Safety·W F MüllerF Korte
Dec 1, 1975·Journal of the National Cancer Institute·R D KimbroughV W Burse
Jun 15, 1976·Zeitschrift Für Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology·A MaekawaM Nakadate
Dec 9, 1976·Zeitschrift Für Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology·N T KimuraT Baba
May 31, 1979·Annals of the New York Academy of Sciences·J R AllenJ P Van Miller
May 31, 1979·Annals of the New York Academy of Sciences·R E Faith, M I Luster
Mar 1, 1978·Journal of Toxicology and Environmental Health·J A NelsonR James
Jan 1, 1979·Epidemiologic Reviews·J L Kelsey
Aug 1, 1977·Bulletin of Environmental Contamination and Toxicology·N I Kerkvliet, D J Kimeldorf
Jun 1, 1979·British Journal of Cancer·L Hardell, A Sandström
Jan 1, 1978·Journal of Agricultural and Food Chemistry·J BitmanV J Feil
Nov 1, 1978·Toxicology and Applied Pharmacology·R J KocibaC G Humiston
Apr 1, 1976·Bulletin of Environmental Contamination and Toxicology·M WassermannD Wassermann
May 15, 1977·International Journal of Cancer. Journal International Du Cancer·S K KashyapS K Chatterjee
Jul 1, 1976·Bulletin of Environmental Contamination and Toxicology·F W KutzR G Lewis
Mar 1, 1992·Toxicology and Applied Pharmacology·R DickersonS Safe
Oct 21, 1992·International Journal of Cancer. Journal International Du Cancer·C A Stiller, D M Parkin
Oct 9, 1992·Science·L S GoldB N Ames
Aug 15, 1992·American Journal of Epidemiology·T SinksR A Shults
Jun 1, 1992·Bulletin of Environmental Contamination and Toxicology·D R VincentS D Allen
Jan 1, 1992·Journal of Biochemical Toxicology·W G FosterP R Lecavalier
Feb 1, 1991·Environmental Health Perspectives·M A Kamrin, L J Fischer
Nov 15, 1990·Cancer·H Mussalo-RauhamaaP Pantzar
May 1, 1991·Breast Cancer Research and Treatment·P G TonioloS Strax
Jan 1, 1991·Reviews of Environmental Contamination and Toxicology·F W KutzD P Bottimore

❮ Previous
Next ❯

Citations

Dec 23, 2006·Cancer Causes & Control : CCC·Nicole M GattoLeslie Bernstein
Nov 3, 2011·Journal of Exposure Science & Environmental Epidemiology·Elvira V BräunerMette Sørensen
May 20, 2003·Proceedings of the National Academy of Sciences of the United States of America·Sara BrunnbergIngemar Pongratz
Apr 8, 2006·Archives of Environmental Health·Ruth KoepkeBrenda Eskenazi
Aug 12, 1999·Archives of Environmental Health·K Jaga
Jan 5, 2002·Food Additives and Contaminants·C A HarrisM W Woolridge
Sep 17, 2004·Food Additives and Contaminants·S M WaliszewskiM Maxwell
Jun 19, 2004·International Journal of Environmental Health Research·Amr S SolimanMelissa L Bondy
Oct 30, 2004·Journal of Toxicology and Environmental Health. Part a·In Young KimAree Moon
Jun 29, 2011·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·M PandelovaK-W Schramm
May 23, 1998·Annual Review of Pharmacology and Toxicology·S H Safe
Jun 5, 1998·Annual Review of Public Health·F Laden, D J Hunter
May 10, 2007·Environmental Health : a Global Access Science Source·Anna Rignell-HydbomMarcello Spano
Dec 16, 2010·Environmental Health Perspectives·Rhena DelportChristiaan de Jager
May 23, 2012·Environmental Health Perspectives·Melyssa R BrattonMatthew E Burow
Mar 4, 2003·Environmental Health Perspectives·Anders Wicklund GlynnElisabete Weiderpass
Jun 25, 1998·Environmental Health Perspectives·F P Guengerich
Apr 16, 1998·Environmental Health Perspectives·T M CrispY M Patel
Jan 5, 1999·Environmental Health Perspectives·F LadenD J Hunter
Apr 15, 2010·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Marta Ociepa-ZawalWieslaw H Trzeciak
Aug 14, 2010·Archives of Environmental & Occupational Health·Barbara A CohnRoberta E Christianson
May 31, 2003·Food Additives and Contaminants·S M WaliszewskiR M Infanzón
Jul 28, 2004·Archives of Microbiology·Manuela GesellFrieder Schauer
Dec 26, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Charbel MassaadSamir Hamamah
Jan 7, 2016·Environment International·Ling LengNai-Jun Tang
Apr 29, 1998·Critical Reviews in Toxicology·R J GoldenE A Reese
Dec 1, 1996·Risk Analysis : an Official Publication of the Society for Risk Analysis·R J Kavlock, G T Ankley
Nov 25, 2003·American Journal of Industrial Medicine·Ana M García
Jul 8, 2010·Environment International·Juan P ArrebolaPiedad Martin-Olmedo
Dec 11, 2007·Comptes rendus biologies·Riadh BadraouiTarek Rebai
May 1, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Mariana F FernandezNicolas Olea

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.