Organochlorine pesticide exposure in essential tremor: a case-control study using biological and occupational exposure assessments.

Neurotoxicology
Elan D LouisMary S Wolff

Abstract

Essential tremor (ET) is a common neurological disorder. Its etiology and pathogenesis are not well understood and several environmental factors (i.e., toxicants) have been studied. Organochlorine pesticides (OCPs) are potent tremor-producing chemicals. These pervasive environmental contaminants have been linked with other tremor disorders (e.g., Parkinson's disease) but they have not been assessed in ET cases. Our objective was to test the hypothesis that ET is associated with OCP exposure. Serum OCP concentrations and lifetime occupational histories were assessed in ET cases and control subjects. Six serum OCP concentrations (p,p'-DDE, p,p'-DDT, beta-hexachlorocyclo-hexane, oxychlordane, trans-nonachlor, and dieldrin) were assessed. Data from a lifetime occupational history were reviewed by a blinded industrial hygienist. The six serum OCP concentrations were similar in 136 ET cases and 144 control subjects. There was no association in ET cases between the six serum OCP concentrations and total tremor score. Three (2.2%) ET cases versus 9 (6.3%) controls had past occupational exposure to OCPs (OR=0.34, 95% CI=0.09-1.28, p=0.10). Although OCPs have been associated with other tremor disorders, we were not able to find an associ...Continue Reading

Citations

Aug 31, 2012·Molecular Neurobiology·Blanca A SilvaVladimir N Uversky
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Jan 25, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C MartínezF J Jiménez-Jiménez
Aug 22, 2008·Neuroepidemiology·Elan D Louis
Nov 17, 2007·Environmental Health Perspectives·Okan DoguHakan Kaleagasi
Sep 20, 2015·Neurotoxicology·Virginia A RauhElan D Louis
Dec 5, 2015·The Cerebellum·Svetlana Iuliana LavițăPierre Duez
Feb 3, 2007·Neurotoxicology·Elan D Louis
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May 30, 2019·Annals of Clinical and Translational Neurology·Yi-Lin OngEng-King Tan

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