Organoid technology for retinal repair

Developmental Biology
Sílvia LlonchMarius Ader

Abstract

A major cause for vision impairment and blindness in industrialized countries is the loss of the light-sensing retinal tissue in the eye. Photoreceptor damage is one of the main characteristics found in retinal degeneration diseases, such as Retinitis Pigmentosa or age-related macular degeneration. The lack of effective therapies to stop photoreceptor loss together with the absence of significant intrinsic regeneration in the human retina converts such degenerative diseases into permanent conditions that are currently irreversible. Cell replacement by means of photoreceptor transplantation has been proposed as a potential approach to tackle cell loss in the retina. Since the first attempt of photoreceptor transplantation in humans, about twenty years ago, several research groups have focused in the development and improvement of technologies necessary to bring cell transplantation for retinal degeneration diseases to reality. Progress in recent years in the generation of human tissue derived from pluripotent stem cells (PSCs) has significantly improved our tools to study human development and disease in the dish. Particularly the availability of 3D culture systems for the generation of PSC-derived organoids, including the human...Continue Reading

Citations

Mar 22, 2018·International Journal of Molecular Sciences·Beatrice Xuan HoBoon-Seng Soh
Aug 11, 2018·PLoS Biology·Marija MatejčićCaren Norden
Aug 23, 2018·Stem Cells·Majlinda Lako
Nov 26, 2019·Translational Science of Rare Diseases·Holly Yu ChenAnand Swaroop
Mar 1, 2020·International Journal of Molecular Sciences·Yuliya Markitantova, Vladimir Simirskii
Jul 3, 2020·Médecine sciences : M/S·Olivier Goureau, Gaël Orieux
Jul 3, 2020·Médecine sciences : M/S·Olivier GoureauGaël Orieux
Jul 30, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Anuradha YadavRajnish Kumar Chaturvedi
Aug 25, 2020·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Daniel JacksonMariya Moosajee
Jul 24, 2018·Translational Vision Science & Technology·Jacque L DuncanUNKNOWN and the Foundation Fighting Blindness Scientific Advisory Board
Nov 18, 2018·Journal of Cellular Physiology·Rahul MittalVasanti M Jhaveri
Dec 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Serge PicaudJosé-Alain Sahel
Jul 3, 2020·OncoTargets and Therapy·Xing XiaoChang-Hua Zhang
Jul 28, 2020·Translational Vision Science & Technology·Phuong T LamMichael L Robinson
Oct 9, 2018·Frontiers in Neuroscience·Oriane RabesandratanaGaël Orieux
Sep 26, 2020·Frontiers in Cellular Neuroscience·Jonathan EintrachtMariya Moosajee
May 21, 2019·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Tiago Santos-FerreiraMarius Ader
Aug 17, 2019·Journal of Developmental Biology·Philippa Harding, Mariya Moosajee
Mar 27, 2020·Frontiers in Cell and Developmental Biology·Mei-Ling GaoZi-Bing Jin
Sep 22, 2020·Current Protocols in Stem Cell Biology·Hannah DöpperDeniz Kanber
Mar 30, 2020·Diabetologia·Anastasia TsakmakiGavin A Bewick
Aug 13, 2018·Bioelectronic Medicine·Eduardo Fernandez
Aug 28, 2020·Frontiers in Neuroscience·Eduardo FernándezPablo González-López
Aug 31, 2020·Light, Science & Applications·Jules SchollerKate Grieve
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Oriane RabesandratanaGael Orieux
Oct 11, 2020·Drug Discovery Today·Wenjing XuanQingguo Xu
Dec 18, 2019·Progress in Retinal and Eye Research·Iqbal AhmadXiaohuan Xia
Jan 5, 2021·Frontiers in Neuroscience·Michael TeliasRichard H Kramer
Dec 29, 2020·Development·Michelle O'Hara-Wright, Anai Gonzalez-Cordero
Mar 9, 2021·Stem Cells International·Gabriella Shih Ping HsiaOswaldo Keith Okamoto
Jul 30, 2020·Progress in Retinal and Eye Research·Sven SchnichelsAlexa Klettner
Mar 20, 2021·Molecular Therapy. Methods & Clinical Development·Anna SalasJosé García-Arumí
Apr 6, 2021·Frontiers in Cellular Neuroscience·Marcela Garita-HernandezDeniz Dalkara
May 13, 2021·3 Biotech·Abhijith ShankaranKapaettu Satyamoorthy
Jul 20, 2021·Frontiers in Cellular Neuroscience·Xuying LiXin Wei

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