Organoids as an in vitro model of human development and disease

Nature Cell Biology
Aliya FatehullahNick Barker

Abstract

The in vitro organoid model is a major technological breakthrough that has already been established as an essential tool in many basic biology and clinical applications. This near-physiological 3D model facilitates an accurate study of a range of in vivo biological processes including tissue renewal, stem cell/niche functions and tissue responses to drugs, mutation or damage. In this Review, we discuss the current achievements, challenges and potential applications of this technique.

References

Mar 23, 2005·Nature Methods·Christopher J FlaimSangeeta N Bhatia
May 6, 2006·Tissue Engineering·Mark J MondrinosChristine M Finck
Jul 19, 2006·Clinical Microbiology Reviews·Johannes G KustersErnst J Kuipers
Sep 15, 2007·Nature Protocols·John R Masters, Glyn N Stacey
Dec 22, 2009·Integrative Biology : Quantitative Biosciences From Nano to Macro·Mark A LaBargeMina J Bissell
Apr 13, 2010·Expert Opinion on Drug Metabolism & Toxicology·Qin Meng
Oct 12, 2010·Differentiation; Research in Biological Diversity·Li CaoCharles Giardina
Apr 9, 2011·Nature·Mototsugu EirakuYoshiki Sasai
Sep 6, 2011·Nature Medicine·Peter JungEduard Batlle
Nov 16, 2011·Nature Protocols·Kyle W McCrackenJason R Spence
Jul 5, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jessica MarianiFlora M Vaccarino
Sep 25, 2012·Nature Cell Biology·Johan H van EsHans Clevers
Jun 4, 2013·Nature Medicine·Johanna F DekkersJeffrey M Beekman
Sep 3, 2013·Nature·Madeline A LancasterJuergen A Knoblich
Oct 17, 2013·Development·Chiara GreggioAnne Grapin-Botton
Nov 19, 2013·Nature Cell Biology·Yun XiaJuan Carlos Izpisua Belmonte
May 2, 2014·Nature Methods·Vivien Marx
May 3, 2014·Nature Protocols·Karl R Koehler, Eri Hashino
May 16, 2014·Tissue Engineering. Part a·Mark J MondrinosPeter I Lelkes
May 23, 2014·Nature Materials·William L MurphyAdam J Engler
Jul 19, 2014·Science·Madeline A Lancaster, Juergen A Knoblich
Sep 5, 2014·Nature Protocols·Madeline A Lancaster, Juergen A Knoblich

❮ Previous
Next ❯

Citations

May 20, 2016·Nature Reviews. Neuroscience·Jerome MertensFred H Gage
Jul 1, 2016·Stem Cell Research & Therapy·Rodolphe BourretJohn De Vos
Jul 2, 2016·Expert Opinion on Drug Discovery·M Cuperlovic-Culf, A S Culf
Aug 5, 2016·Nature Protocols·Mo Li, Juan Carlos Izpisua Belmonte
Oct 8, 2016·Frontiers in Pharmacology·Fangkun LiuWei Zhao
Oct 14, 2016·Stem Cells and Development·Maurizio PesceAntonio Paolo Beltrami
Nov 1, 2016·Nature Reviews. Genetics·Benjamin E HousdenNorbert Perrimon
Dec 17, 2016·Nature Reviews. Drug Discovery·Yanhong ShiShinya Yamanaka
Jan 21, 2017·Science·Annelien L BredenoordJuergen A Knoblich
Jan 18, 2017·Expert Opinion on Drug Discovery·Mohammad-Reza Rashidi, Somaieh Soltani
Dec 3, 2016·Scientific Reports·Alexis GonneaudFrançois-Michel Boisvert
Apr 7, 2017·ACS Applied Materials & Interfaces·Anna Li VolsiGaetano Giammona
Dec 30, 2016·The Journal of Cell Biology·Marina Simian, Mina J Bissell
Mar 28, 2017·Trends in Molecular Medicine·Devanjali DuttaHans Clevers
May 5, 2017·Nature Reviews. Neuroscience·Christoph Anacker, René Hen
Dec 24, 2016·Cell Reports·Chongyuan LuoJoseph R Ecker
Oct 4, 2016·Lancet Neurology·Alan C EvansYasser Iturria-Medina
May 18, 2017·Nature Chemical Biology·Andrei UrsuHerbert Waldmann
Jun 1, 2017·Nature Biotechnology·Madeline A LancasterJuergen A Knoblich
Nov 27, 2016·Journal of Gastroenterology·Tetsuya Nakamura, Mamoru Watanabe
Feb 22, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Ninouk Akkerman, Libert H K Defize
Apr 20, 2017·Journal of the National Cancer Institute·Lu Zhang, Jerry W Shay
Feb 12, 2017·Trends in Molecular Medicine·Ryuji Morizane, Joseph V Bonventre
Jul 29, 2017·Lab on a Chip·Yujuan ZhuJianhua Qin
Feb 22, 2018·International Journal of Molecular Sciences·Gianluca ColellaFilomena de Nigris
Feb 22, 2018·Nature Reviews. Gastroenterology & Hepatology·José B Sáenz, Jason C Mills
Jan 30, 2018·Journal of Cellular Biochemistry·Ali GolchinAbdolreza Ardeshirylajimi
Feb 17, 2018·Integrative Biology : Quantitative Biosciences From Nano to Macro·Bianca N LourençoClaudia Fischbach
Mar 10, 2018·The Journal of Pathology·Ravi Kiran DeeviFrederick Charles Campbell
Mar 7, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Shinji OkanoKoji Hashimoto
Mar 5, 2018·Journal of Cellular and Molecular Medicine·Elena AbatiStefania Corti
Jan 20, 2018·Advanced Healthcare Materials·Darren RodenhizerAlison P McGuigan
Jun 1, 2017·Molecular Biology of the Cell·David G Drubin, Anthony A Hyman
Apr 11, 2018·Nature Chemical Biology·Aaron H NileRami N Hannoush
Jun 24, 2017·Proteomics·Alexis GonneaudFrançois-Michel Boisvert
Oct 16, 2016·Integrative Biology : Quantitative Biosciences From Nano to Macro·Mariia LunovaAlexandr Dejneka
Nov 1, 2017·Nature Cell Biology·Jeffrey W Brown, Jason C Mills

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.