PMID: 26911908DOI: 10.1038/ncb3312Feb 26, 2016Paper
Organoids as an in vitro model of human development and disease
Nature Cell Biology
Aliya FatehullahNick Barker
Abstract
The in vitro organoid model is a major technological breakthrough that has already been established as an essential tool in many basic biology and clinical applications. This near-physiological 3D model facilitates an accurate study of a range of in vivo biological processes including tissue renewal, stem cell/niche functions and tissue responses to drugs, mutation or damage. In this Review, we discuss the current achievements, challenges and potential applications of this technique.
References
Mar 23, 2005·Nature Methods·Christopher J FlaimSangeeta N Bhatia
May 6, 2006·Tissue Engineering·Mark J MondrinosChristine M Finck
Jul 6, 2006·Molecular Systems Biology·Yoav SoenPatrick O Brown
Jul 19, 2006·Clinical Microbiology Reviews·Johannes G KustersErnst J Kuipers
Aug 15, 2006·Cell·Kazutoshi Takahashi, Shinya Yamanaka
Sep 15, 2007·Nature Protocols·John R Masters, Glyn N Stacey
Mar 31, 2009·Nature·Toshiro SatoHans Clevers
Apr 29, 2009·Nature Medicine·Akifumi OotaniCalvin J Kuo
Dec 22, 2009·Integrative Biology : Quantitative Biosciences From Nano to Macro·Mark A LaBargeMina J Bissell
Jan 21, 2010·Cell Stem Cell·Nick BarkerHans Clevers
Apr 13, 2010·Expert Opinion on Drug Metabolism & Toxicology·Qin Meng
Oct 12, 2010·Differentiation; Research in Biological Diversity·Li CaoCharles Giardina
Nov 30, 2010·Nature·Toshiro SatoHans Clevers
Dec 15, 2010·Nature·Jason R SpenceJames M Wells
Apr 9, 2011·Nature·Mototsugu EirakuYoshiki Sasai
Apr 22, 2011·EMBO Reports·Roxana C MustataMarie-Isabelle Garcia
May 17, 2011·PloS One·Maria João ValenteMárcia Carvalho
Sep 6, 2011·Gastroenterology·Toshiro SatoHans Clevers
Sep 6, 2011·Nature Medicine·Peter JungEduard Batlle
Nov 16, 2011·Nature Protocols·Kyle W McCrackenJason R Spence
Mar 13, 2012·Nature Medicine·Shiro YuiMamoru Watanabe
Jul 5, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jessica MarianiFlora M Vaccarino
Jul 5, 2012·MBio·Stacy R FinkbeinerMary K Estes
Sep 25, 2012·Nature Cell Biology·Johan H van EsHans Clevers
Jan 29, 2013·Nature·Meritxell HuchHans Clevers
Jun 4, 2013·Nature Medicine·Johanna F DekkersJeffrey M Beekman
Jul 5, 2013·Nature·Takanori TakebeHideki Taniguchi
Jul 12, 2013·Nature·Karl R KoehlerEri Hashino
Sep 3, 2013·Nature·Madeline A LancasterJuergen A Knoblich
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis
Sep 21, 2013·The EMBO Journal·Meritxell HuchHans Clevers
Oct 12, 2013·Molecular Carcinogenesis·Li CaoCharles Giardina
Oct 15, 2013·Cell·Daniel E StangeHans Clevers
Oct 17, 2013·Development·Chiara GreggioAnne Grapin-Botton
Oct 22, 2013·Cell Stem Cell·Robert P FordhamKim B Jensen
Oct 22, 2013·Cell Reports·Roxana C MustataMarie-Isabelle Garcia
Nov 16, 2013·Scientific Reports·Hiroko HishaHiroo Ueno
Nov 19, 2013·Nature Cell Biology·Yun XiaJuan Carlos Izpisua Belmonte
Dec 3, 2013·Nature Methods·Xiaolei YinJeffrey M Karp
Dec 18, 2013·Cell Stem Cell·Atsuhiro TaguchiRyuichi Nishinakamura
Dec 18, 2013·Nature Cell Biology·M TakasatoM H Little
Jan 25, 2014·Nature Protocols·Takanori TakebeHideki Taniguchi
May 2, 2014·Nature Methods·Vivien Marx
May 3, 2014·Nature Protocols·Karl R Koehler, Eri Hashino
May 16, 2014·Tissue Engineering. Part a·Mark J MondrinosPeter I Lelkes
May 23, 2014·Nature Materials·William L MurphyAdam J Engler
May 27, 2014·Nature Medicine·Xingnan LiCalvin J Kuo
Jul 19, 2014·Science·Madeline A Lancaster, Juergen A Knoblich
Aug 16, 2014·Gut·Lydia E WroblewskiRichard M Peek
Aug 17, 2014·Genes & Development·Masayoshi FukudaTetsuya Nakamura
Sep 5, 2014·Nature Protocols·Madeline A Lancaster, Juergen A Knoblich
❮ Previous
Next ❯
Citations
May 20, 2016·Nature Reviews. Neuroscience·Jerome MertensFred H Gage
Jul 1, 2016·Stem Cell Research & Therapy·Rodolphe BourretJohn De Vos
Jul 2, 2016·Expert Opinion on Drug Discovery·M Cuperlovic-Culf, A S Culf
Aug 5, 2016·Nature Protocols·Mo Li, Juan Carlos Izpisua Belmonte
Oct 8, 2016·Frontiers in Pharmacology·Fangkun LiuWei Zhao
Nov 2, 2016·ELife·Briana R DyeJason R Spence
Oct 14, 2016·Stem Cells and Development·Maurizio PesceAntonio Paolo Beltrami
Nov 1, 2016·Nature Reviews. Genetics·Benjamin E HousdenNorbert Perrimon
Dec 17, 2016·Nature Reviews. Drug Discovery·Yanhong ShiShinya Yamanaka
Jan 21, 2017·Science·Annelien L BredenoordJuergen A Knoblich
Jan 18, 2017·Expert Opinion on Drug Discovery·Mohammad-Reza Rashidi, Somaieh Soltani
Dec 3, 2016·Scientific Reports·Alexis GonneaudFrançois-Michel Boisvert
Apr 7, 2017·ACS Applied Materials & Interfaces·Anna Li VolsiGaetano Giammona
Dec 30, 2016·The Journal of Cell Biology·Marina Simian, Mina J Bissell
Feb 6, 2017·Acta Biomaterialia·Shivem B Shah, Ankur Singh
Mar 28, 2017·Trends in Molecular Medicine·Devanjali DuttaHans Clevers
Feb 25, 2017·Neuropathology and Applied Neurobiology·M-Y SonJ Kim
May 5, 2017·Nature Reviews. Neuroscience·Christoph Anacker, René Hen
Dec 24, 2016·Cell Reports·Chongyuan LuoJoseph R Ecker
Oct 4, 2016·Lancet Neurology·Alan C EvansYasser Iturria-Medina
May 18, 2017·Nature Chemical Biology·Andrei UrsuHerbert Waldmann
May 24, 2017·Expert Review of Proteomics·Miroslava StastnaJennifer E Van Eyk
Jun 1, 2017·Nature Biotechnology·Madeline A LancasterJuergen A Knoblich
Nov 27, 2016·Journal of Gastroenterology·Tetsuya Nakamura, Mamoru Watanabe
Dec 7, 2016·Nature Medicine·Eirini P Papapetrou
Feb 22, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Ninouk Akkerman, Libert H K Defize
Apr 20, 2017·Journal of the National Cancer Institute·Lu Zhang, Jerry W Shay
Feb 12, 2017·Trends in Molecular Medicine·Ryuji Morizane, Joseph V Bonventre
Jul 29, 2017·Lab on a Chip·Yujuan ZhuJianhua Qin
Feb 22, 2018·International Journal of Molecular Sciences·Gianluca ColellaFilomena de Nigris
Feb 22, 2018·Nature Reviews. Gastroenterology & Hepatology·José B Sáenz, Jason C Mills
Jan 30, 2018·Journal of Cellular Biochemistry·Ali GolchinAbdolreza Ardeshirylajimi
Mar 16, 2018·SLAS Discovery·Bárbara da SilvaHeiko Wurdak
Mar 6, 2018·PLoS Pathogens·Avantika S ChitreJoseph M McCune
Mar 16, 2018·Nature Protocols·Plansky HoangZhen Ma
Feb 17, 2018·Integrative Biology : Quantitative Biosciences From Nano to Macro·Bianca N LourençoClaudia Fischbach
Oct 5, 2017·Materials·Kyung-Joon MinJeong-Woo Choi
Mar 10, 2018·Bioengineering·Krzysztof Wrzesinski, Stephen J Fey
Mar 10, 2018·The Journal of Pathology·Ravi Kiran DeeviFrederick Charles Campbell
Dec 14, 2017·The AAPS Journal·Jonathan P MochelKarin Allenspach
Mar 7, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Shinji OkanoKoji Hashimoto
Mar 5, 2018·Journal of Cellular and Molecular Medicine·Elena AbatiStefania Corti
Jan 20, 2018·Advanced Healthcare Materials·Darren RodenhizerAlison P McGuigan
Jun 1, 2017·Molecular Biology of the Cell·David G Drubin, Anthony A Hyman
Apr 11, 2018·Nature Chemical Biology·Aaron H NileRami N Hannoush
Feb 8, 2018·Frontiers in Pharmacology·Sigrid A Langhans
Jun 24, 2017·Proteomics·Alexis GonneaudFrançois-Michel Boisvert
Oct 16, 2016·Integrative Biology : Quantitative Biosciences From Nano to Macro·Mariia LunovaAlexandr Dejneka
Feb 18, 2017·Biofabrication·Kerstin SchneebergerJos Malda
Nov 1, 2017·Nature Cell Biology·Jeffrey W Brown, Jason C Mills
❮ Previous
Next ❯
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