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Organophosphorus nerve agents-induced seizures and efficacy of atropine sulfate as anticonvulsant treatment

Pharmacology, Biochemistry, and Behavior

Sep 1, 1999

T M Shih, John H McDonough

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Abstract

The ability of five organophosphorus nerve agents (tabun, sarin, soman, GF, and VX) to produce brain seizures and the effectiveness of atropine as an anticonvulsant treatment against these nerve agents were studied in two different animal models--the rat and guinea pig. All animals were...read more

Mentioned in this Paper

Atropine Sulfate Anhydrous
Pseudocholinesterase
Muscarinic Antagonists
Metazoa
Atropinum, atropine
Rats, Holtzman
Electroencephalogram
Organopyrophosphorus Compounds
Adrenal Cortex
Pralidoxime
Paper Details
References
  • References22
  • Citations50
123
  • References22
  • Citations50
12345

Organophosphorus nerve agents-induced seizures and efficacy of atropine sulfate as anticonvulsant treatment

Pharmacology, Biochemistry, and Behavior

Sep 1, 1999

T M Shih, John H McDonough

PMID: 10495009

DOI: 10.1016/s0091-3057(99)00114-8

Abstract

The ability of five organophosphorus nerve agents (tabun, sarin, soman, GF, and VX) to produce brain seizures and the effectiveness of atropine as an anticonvulsant treatment against these nerve agents were studied in two different animal models--the rat and guinea pig. All animals were...read more

Mentioned in this Paper

Atropine Sulfate Anhydrous
Pseudocholinesterase
Muscarinic Antagonists
Metazoa
Atropinum, atropine

Related Papers

Paper Details
References
  • References22
  • Citations50
123
  • References22
  • Citations50
12345

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