Organoselenium improves memory decline in mice: involvement of acetylcholinesterase activity

Neuroscience Letters
Simone PintonCristina Wayne Nogueira

Abstract

The present study was designed to investigate the possible neuroprotective effect of p,p'-methoxyl-diphenyl diselenide [(MeOPhSe)(2)] in a model of sporadic dementia of Alzheimer's type (SDAT) induced by intracerebroventricular (i.c.v.) injection of streptozotocin (STZ) in mice. Mice were divided into four groups: (I) control, (II) (MeOPhSe)(2), (III) STZ, and (IV) (MeOPhSe)(2)+STZ. Mice were exposed to (MeOPhSe)(2) (25mg/kg, by gavage) and STZ (2mul of 2.5mg/ml solution; i.c.v.) or vehicles. 48 after that the exposure was repeated. Learning and memory were assessed with the step-down-type passive-avoidance (SDPA) and Morris water-maze (MWM) tests at the days 5-6 and 6-9, respectively. At the end of the experimental protocol animals were euthanized and cerebral cortex was removed for acetylcholinesterase (AChE) activity assay. Our results confirmed that i.c.v. STZ caused learning and memory deficits in mice, which were verified using the MWM and SDPA tasks. Furthermore, this study showed that AChE activity was increased in mice that received i.c.v. STZ. The most important findings of the present study are that (MeOPhSe)(2) was able to reverse the learning and memory impairments induced by STZ, and to protect against the increas...Continue Reading

References

Jul 1, 1976·Journal of Neurochemistry·G E Gibson, J P Blass
Dec 1, 1986·Journal of Pharmacological Methods·S E Laursen, J K Belknap
Aug 1, 1993·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·K Plaschke, S Hoyer
Mar 14, 2000·Physiology & Behavior·C R ParkS C Woods
Mar 1, 1957·British Journal of Pharmacology and Chemotherapy·T J HALEY, W G MCCORMICK
Dec 9, 2004·Chemical Reviews·Cristina W NogueiraJoão B T Rocha
Dec 20, 2005·European Journal of Pharmacology·Minoru SakaguchiEiko Matsumura
Feb 26, 2008·Brain Research·Eluza Curte StangherlinCristina Wayne Nogueira
Jan 27, 2009·Life Sciences·Ana Cristina G SouzaCristina W Nogueira
Apr 22, 2009·Biogerontology·Najma Z BaquerDeepak Sharma

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Citations

Jul 2, 2011·Archives of Toxicology·Cristina W Nogueira, João B T Rocha
Jan 18, 2011·Organic & Biomolecular Chemistry·Leandro PiovanLeandro H Andrade
Sep 10, 2013·Neurochemical Research·Gabriela Lorea GodoiHiram Larangeira de Almeida
Jan 5, 2012·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M T MeloR M Rosa
Apr 26, 2011·Behavioural Brain Research·Simone PintonCristina Wayne Nogueira
Sep 11, 2012·The Journal of Nutritional Biochemistry·Simone PintonCristina Wayne Nogueira
Sep 15, 2015·Pharmacology, Biochemistry, and Behavior·Roberto Laureano-MeloWellington da Silva Côrtes
Apr 5, 2013·Journal of Neuroscience Research·Ana Cristina Guerra SouzaCristina Wayne Nogueira
May 15, 2015·European Journal of Medicinal Chemistry·Saad ShaabanLudger A Wessjohann
Apr 30, 2015·Organic & Biomolecular Chemistry·Marcio S Silva, Leandro H Andrade
May 1, 2012·Molecular and Cellular Biochemistry·Cristiane LucheseCristina W Nogueira
Apr 18, 2018·Current Drug Discovery Technologies·Kirtee Baheti, Mayura Kale
Sep 23, 2014·Expert Review of Neurotherapeutics·Fabio Di DomenicoD Allan Butterfield
Jan 15, 2020·Canadian Journal of Physiology and Pharmacology·Harmandeep SinghJitender Madan
Feb 5, 2021·The Journal of Physical Chemistry. B·Amit KumawatMasood Ahmad Rizvi
Apr 2, 2021·Archives of Toxicology·Cristina W NogueiraJoão B T Rocha

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