Organosilica-Based Hollow Mesoporous Bilirubin Nanoparticles for Antioxidation-Activated Self-Protection and Tumor-Specific Deoxygenation-Driven Synergistic Therapy

ACS Nano
Lingling ShanXiaoyuan Chen

Abstract

A major concern about glucose oxidase (GOx)-mediated cancer starvation therapy is its ability to induce serious oxidative damage to normal tissues through the massive production of H2O2 byproducts in the oxygen-involved glucose decomposition reaction, which may be addressed by using a H2O2 scavenger, known as an antioxidation agent. Surprisingly, H2O2 removal accelerates the aerobic glycometabolism of tumors by activating the H2O2-dependent "redox signaling" pathway of cancer cells. Simultaneous oxygen depletion further aggravates tumor hypoxia to increase the toxicity of a bioreductive prodrug, such as tirapazamine (TPZ), thereby improving the effectiveness of cancer starvation therapy and bioreductive chemotherapy. Herein, a "nitrogen-protected silica template" method is proposed to design a nanoantioxidant called an organosilica-based hollow mesoporous bilirubin nanoparticle (HMBRN), which can act as an excellent nanocarrier to codeliver GOx and TPZ. In addition to efficient removal of H2O2 for self-protection of normal tissues via antioxidation, GOx/TPZ-coloaded HMBRN can also rapidly deplete intratumoral glucose/oxygen to promote a synergistic starvation-enhanced bioreductive chemotherapeutic effect for the substantial sup...Continue Reading

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Citations

May 20, 2020·International Journal of Nanomedicine·Weiwei WangLingling Shan
Oct 10, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xinhe LiuZhihui Dai
Sep 4, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Qing YaoLongfa Kou
Mar 31, 2021·Clinical and Translational Medicine·Zhencong ChenLijie Tan
Apr 27, 2021·ACS Nano·Qiuhong ZhangYanli Zhao
Aug 9, 2021·Journal of Colloid and Interface Science·Liping ZhaoWeifen Zhang
Feb 12, 2020·ACS Applied Materials & Interfaces·Lewis D BlackmanKatherine E S Locock
Aug 31, 2021·Frontiers in Chemistry·Xiurong SunYingxia Ning
Oct 15, 2021·Biomaterials Science·Di LiHongwei Duan

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