PMID: 11342170May 9, 2001Paper

Organotin compounds alter the physical organization of phosphatidylcholine membranes

Biochimica Et Biophysica Acta
José J ChicanoFrancisco J Aranda

Abstract

Organotin compounds have a broad range of biological activities and are ubiquitous contaminants in the environment. Their toxicity mainly lies in their action on the membrane. In this contribution we study the interaction of tributyltin and triphenyltin with model membranes composed of phosphatidylcholines of different acyl chain lengths using differential scanning calorimetry, (31)P-nuclear magnetic resonance, X-ray diffraction and infrared spectroscopy. Organotin compounds broaden the main gel to liquid-crystalline phase transition, shift the transition temperature to lower values and induce the appearance of a new peak below the main transition peak. These effects are more pronounced in the case of tributyltin and are quantitatively larger as the phosphatidylcholine acyl chain length decreases. Both tributyltin and triphenyltin increase the enthalpy change of the transition in all the phosphatidylcholine systems studied except in dilauroylphosphatidylcholine. Organotin compounds do not affect the macroscopic bilayer organization of the phospholipid but do affect the degree of hydration of its carbonyl moiety. The above evidence supports the idea that organotin compounds are located in the upper part of the phospholipid palis...Continue Reading

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Citations

Nov 3, 2005·Environmental Health Perspectives·Atanas G AtanasovAlex Odermatt
Mar 15, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Salvatore NesciAlessandra Pagliarani
Oct 19, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Salvatore NesciAlessandra Pagliarani
Dec 29, 2015·Journal of Photochemistry and Photobiology. B, Biology·Farooq Ali ShahNoor ud Din
Feb 14, 2006·Biochimica Et Biophysica Acta·Antonio OrtizFrancisco J Aranda
Dec 26, 2001·Biochimica Et Biophysica Acta·José J ChicanoFrancisco J Aranda
Jul 29, 2006·International Journal of Pharmaceutics·Antonio OrtizFrancisco J Aranda
Aug 3, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J D MartinsV M C Madeira
Aug 6, 2014·Biochimica Et Biophysica Acta·Seza ErgunFeride Severcan
Feb 12, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Alessandra PagliaraniAnna Rosa Borgatti
Jul 8, 2014·Journal of Biomolecular Structure & Dynamics·Scheherezade García-CarrilloJosé A Teruel
May 12, 2009·Cell Biology International·Romuald ZyłkaStanislaw Przestalski
Oct 30, 2003·Journal of the American Chemical Society·Bethany BuckGianluigi Veglia

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