Organotin compounds enhance 17beta-hydroxysteroid dehydrogenase type I activity in human choriocarcinoma JAr cells: potential promotion of 17beta-estradiol biosynthesis in human placenta

Biochemical Pharmacology
T NakanishiKeiichi Tanaka

Abstract

Organotin compounds, such as tributyltin (TBT) and triphenyltin (TPT), are typical environmental contaminants and suspected endocrine-disrupting chemicals because they cause masculinization in female mollusks. However, it remains unclear whether organotin compounds also cause crucial toxicities in human sexual development and reproductive functions. We investigated the effects of 17 tin compounds on the catalytic activity and mRNA expression of 17beta-hydroxysteroid dehydrogenase type I (17beta-HSD I) in human choriocarcinoma JAr cells. At nontoxic concentrations, both trialkyltins with propyl, butyl or cyclohexyl substituents on the tin atom and triphenyltin (TPT) enhanced 17beta-HSD I mRNA transcription and enzyme activity in a dose-dependent fashion. Although tetraalkyltin compounds such as tetrabutyltin and tributylvinyltin also increased the mRNA expression and enzyme activity of 17beta-HSD I, the concentrations necessary for activation were >30-100 times greater than those for trialkyltins. Inorganic tin had no effect on the catalytic activity and mRNA expression of 17beta-HSD I. Interestingly, diphenyltin and monophenyltin, which are metabolites of TPT, enhanced 17beta-HSD I activity with a concomitant increase in mRNA e...Continue Reading

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Citations

Jun 6, 2009·Chemico-biological Interactions·Youhei HiromoriTsuyoshi Nakanishi
Aug 3, 2012·Journal of Toxicology and Environmental Health. Part a·Priscila Lang PodratzJones Bernardes Graceli
Mar 26, 2013·Toxicology and Applied Pharmacology·Shruti SharanPartha Roy
Dec 12, 2012·Reproductive Toxicology·Jones Bernardes GraceliMarcos Antonio Dos Santos Fernandez
May 5, 2009·General and Comparative Endocrinology·Kenji ItohTsuyoshi Nakanishi
Dec 4, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Youhei HiromoriTsuyoshi Nakanishi
Apr 3, 2012·The Journal of Toxicological Sciences·Ryo KobayashiHisamitsu Nagase
Nov 6, 2012·Biological & Pharmaceutical Bulletin·Yaichiro Kotake
Feb 18, 2015·Scientific Reports·Shusaku HaradaTsuyoshi Nakanishi
Aug 31, 2011·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·V S Delgado FilhoJ B Graceli
Mar 16, 2018·Journal of Perinatal Medicine·Yuko AritaMorgan R Peltier
Sep 4, 2020·The Journal of Toxicological Sciences·Katsuya YamamotoTsuyoshi Nakanishi
Mar 17, 2018·Frontiers in Endocrinology·Julia Fernandez Puñal de AraújoJones Bernardes Graceli
Apr 3, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Isabela V SarmentoJones B Graceli
Apr 23, 2008·The Biochemical Journal·Françoise Raffalli-MathieuBengt Mannervik
Sep 17, 2013·Journal of Applied Toxicology : JAT·Lindsay J Celada, Margaret M Whalen
Apr 5, 2018·Frontiers in Endocrinology·Vinicius Bermond MarquesLeonardo Dos Santos
Jan 4, 2021·Endocrine Reviews·Vasantha PadmanabhanMuraly Puttabyatappa

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