Organs-on-chips at the frontiers of drug discovery

Nature Reviews. Drug Discovery
Eric W EschDongeun Huh

Abstract

Improving the effectiveness of preclinical predictions of human drug responses is critical to reducing costly failures in clinical trials. Recent advances in cell biology, microfabrication and microfluidics have enabled the development of microengineered models of the functional units of human organs - known as organs-on-chips - that could provide the basis for preclinical assays with greater predictive power. Here, we examine the new opportunities for the application of organ-on-chip technologies in a range of areas in preclinical drug discovery, such as target identification and validation, target-based screening, and phenotypic screening. We also discuss emerging drug discovery opportunities enabled by organs-on-chips, as well as important challenges in realizing the full potential of this technology.

References

Nov 2, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S N BhatiaM Toner
Oct 13, 2000·Regulatory Toxicology and Pharmacology : RTP·H OlsonA Heller
Jul 12, 2001·Annual Review of Biomedical Engineering·G M WhitesidesD E Ingber
Nov 10, 2001·Annual Review of Biomedical Engineering·A Folch, M Toner
Jul 16, 2002·Annual Review of Biomedical Engineering·David J BeebeGlenn M Walker
Aug 3, 2004·Nature Reviews. Drug Discovery·Ismail Kola, John Landis
Mar 23, 2005·Nature Methods·Christopher J FlaimSangeeta N Bhatia
Feb 24, 2006·Nature Reviews. Molecular Cell Biology·Linda G Griffith, Melody A Swartz
Mar 1, 2006·Pharmacotherapy·Harold J DemonacoEric von Hippel
Jul 28, 2006·Nature·George M Whitesides
Jul 28, 2006·Nature·Jamil El-AliKlavs F Jensen
Nov 10, 2006·Advanced Drug Delivery Reviews·Vladimir P Torchilin
Jul 24, 2007·Nature Reviews. Drug Discovery·Jeffrey A KramerDale L Morris
Sep 4, 2007·Nature Methods·Claudia FischbachDavid J Mooney
Nov 21, 2007·Nature Biotechnology·Salman R Khetani, Sangeeta N Bhatia
Apr 25, 2008·Lab on a Chip·Ivar MeyvantssonDavid J Beebe
Jan 13, 2009·Biotechnology and Bioengineering·Daniel A Tatosian, Michael L Shuler
Jul 10, 2009·Chemical Society Reviews·Elodie Boisselier, Didier Astruc
Feb 4, 2010·Lab on a Chip·Jong Hwan SungMichael L Shuler
Feb 20, 2010·Nature Reviews. Drug Discovery·Steven M PaulAaron L Schacht
Apr 2, 2010·Microfluidics and Nanofluidics·Ieong Wong, Chih-Ming Ho
Apr 2, 2010·Lab on a Chip·Yevgeny BerdichevskyMartin L Yarmush
Jun 26, 2010·Science·Dongeun HuhDonald E Ingber
Mar 2, 2011·Nature Reviews. Drug Discovery·Giordano Caponigro, William R Sellers
Apr 26, 2011·Annual Review of Biomedical Engineering·M B EschM L Shuler
Jun 28, 2011·Nature Reviews. Drug Discovery·David C Swinney, Jason Anthony
Jul 5, 2011·Current Opinion in Biotechnology·Niraj K Inamdar, Jeffrey T Borenstein
Jul 26, 2011·Lab on a Chip·Ebrahim Ghafar-ZadehLuke P Lee
Sep 29, 2011·Expert Opinion on Drug Metabolism & Toxicology·Viet Hong PhanStephen J Clarke
Oct 29, 2011·Trends in Cell Biology·Dongeun HuhDonald E Ingber
Nov 19, 2011·Drug Discovery Today·Amir M GhaemmaghamiAli Khademhosseini
Feb 10, 2012·Lab on a Chip·Erwin BerthierDavid Beebe
Mar 2, 2012·Nature Reviews. Drug Discovery·Jack W ScannellBrian Warrington
Mar 6, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Andries D van der Meer, Albert van den Berg
Mar 14, 2012·Journal of Medicinal Chemistry·Jonathan A LeeDaniel J Sall
Mar 28, 2012·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Yuki ImuraKiichi Sato
Mar 31, 2012·Nature Reviews. Drug Discovery·Irena Melnikova
May 5, 2012·Lab on a Chip·Dongeun HuhDonald E Ingber
May 16, 2012·Critical Reviews in Toxicology·Edward L LeCluyseMark J Powers

❮ Previous
Next ❯

Citations

Oct 31, 2015·Annual Review of Animal Biosciences·William C Campbell
Nov 26, 2015·Expert Opinion on Drug Discovery·Bridget K Wagner
Feb 11, 2016·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Jenna UsprechCraig A Simmons
Nov 28, 2015·Nature Reviews. Drug Discovery·Chenchen Song, Thomas Knöpfel
Feb 20, 2016·Angewandte Chemie·Falguni PatiHelene Andersson Svahn
Feb 13, 2016·Biomicrofluidics·P EribolK O Ulgen
Sep 12, 2015·Thrombosis and Haemostasis·A BalduiniD L Kaplan
Dec 2, 2015·Analytical Chemistry·Michael G Roper
Nov 21, 2015·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Dinelia Rivera-BurgosSteven R Tannenbaum
Jan 7, 2016·Chemical Research in Toxicology·Richard A ThompsonDominic P Williams
Nov 3, 2015·Seminars in Cell & Developmental Biology·Timothy Krüger, Markus Engstler
Feb 20, 2016·Expert Review of Molecular Diagnostics·Bjørn T GjertsenJörn Skavland
Mar 22, 2016·Lab on a Chip·Weijia ZhangAli Khademhosseini
Mar 5, 2016·Expert Opinion on Drug Metabolism & Toxicology·Abhinav BhushanMartin L Yarmush
Apr 20, 2016·Advanced Healthcare Materials·Zongbin LiuLidong Qin
Apr 6, 2016·Current Opinion in Biotechnology·A Milunović-JevtićJ C Gatlin
Apr 5, 2016·Analytical Chemistry·James F Rusling, Eli G Hvastkovs
Jul 25, 2015·Nature Reviews. Drug Discovery·Anthony HolmesDavid Jones
Jul 15, 2015·Lab on a Chip·Yoonseok ChoiDongeun Huh
Apr 12, 2016·Pharmacology & Therapeutics·Sritama Nath, Gayathri R Devi
May 31, 2016·Advanced Healthcare Materials·Keely A HeintzJohn H Slater
Jun 4, 2016·Current Opinion in Cell Biology·Hyun Koo, Kenneth M Yamada
Jun 7, 2016·Drug Discovery Today·Lambert I J C BergersSusan Gibbs
Jun 15, 2016·Trends in Biotechnology·Weijie PengIbrahim T Ozbolat
Jul 8, 2016·Scientific Reports·Lipin ChenShihao Sun
Jul 17, 2016·Drug Discovery Today·Aleksander SkardalAnthony Atala
Aug 9, 2016·Trends in Biotechnology·Nathalie Picollet-D'hahanDonald K Martin
Aug 9, 2016·Bulletin of Experimental Biology and Medicine·O V SemenovaD A Sakharov
Aug 16, 2016·Biosensors & Bioelectronics·Islam Bogachan TahirbegiTorsten Mayr
Aug 20, 2016·Rapid Communications in Mass Spectrometry : RCM·Jing WuJin-Ming Lin
Aug 26, 2016·Lab on a Chip·Patrícia Moura RosaØyvind Halaas
Aug 28, 2016·Drug Discovery Today·Diana Gaspar, Dimitrios I Zeugolis
Jul 23, 2016·Clinical Pharmacology and Therapeutics·S Y ChangE J Kelly
Sep 2, 2016·Nature Protocols·Ali Khademhosseini, Robert Langer
Sep 9, 2016·Integrative Biology : Quantitative Biosciences From Nano to Macro·Zhongyu LiJianhua Qin
Nov 4, 2016·Nature Reviews. Drug Discovery·Peter HorvathNeil O Carragher

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Related Papers

Drug Discovery Today
Amir M GhaemmaghamiAli Khademhosseini
Methods in Molecular Biology
Shelley D Minteer, Christine M Moore
Journal of the Royal Society, Interface
Shelly GulatiAndrew J deMello
© 2021 Meta ULC. All rights reserved