Organs transplanted from intoxicated donors

Transplantation Proceedings
E DuqueM Arbeláez

Abstract

The purpose of our study was to evaluate short- and long-term results of transplants from cadaver donors who have died of poisoning by various substances. The actuarial survival rate of organs from intoxicated donors was calculated using the Kaplan-Meier method. Among the 507 donors between January 1998 and December 2002, 5 (0.98%) had a cause of brain death of poisoning, namely, organo-phosphates (n = 2), methanol (n = 1), cyanide (n = 1) and acetylsalicilic acid(n = 1), from whom were procured 10 kidneys, 1 liver, 2 corneas, and 1 set of bones. The follow up for patients receiving solid organs was 15.2 months (range, 0-48 months). At 3 months, 90% of kidneys had normal function. No delayed graft function rejection episodes or major complications were reported in any recipient. None showed evidence of acute or chronic poisoning. Two died, 1 early mortality was due to anesthetic complications and the other at 17 months to an unknown cause. Actuarial kidney survival rates were 90% and 80% at 12 and 24 months, respectively. The liver recipient was well at the end of follow up. Using organs of poisoned donors is feasible with comparable graft survival rates to other recipient.

References

Jan 1, 1995·Transplant International : Official Journal of the European Society for Organ Transplantation·P HantsonP Mahieu
May 16, 2002·Clinical Transplantation·A López-NavidadM A Frutos

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Citations

Jun 13, 2014·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Peter SklienkaDana Streitová
Nov 5, 2015·American Journal of Lifestyle Medicine·Nicole Dawson, Heather Menne
Jul 11, 2018·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Umesh MistryDavid M Wood
Sep 22, 2021·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Farangis SadeghiMitra Rahimi

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