Oriented cell division affects the global stress and cell packing geometry of a monolayer under stretch

Journal of Biomechanics
Guang-Kui XuZhaoliang Zheng

Abstract

Cell division plays a vital role in tissue morphogenesis and homeostasis, and the division plane is crucial for cell fate. For isolated cells, extensive studies show that the orientation of divisions is sensitive to cell shape and the direction of extrinsic mechanical forces. However, it is poorly understood that how the cell divides within a cell monolayer and how the local stress change, due to the division, affects the global stress of epithelial monolayers. Here, we use the vertex dynamics models to investigate the effects of division orientation on the configurations and mechanics of a cell monolayer under stretch. We examine three scenarios of the divisions: dividing along the stretch axis, dividing along the geometric long axis of cells, and dividing at a random angle. It is found that the division along the long cell axis can induce the minimal energy difference, and the global stress of the monolayer after stretch releases more rapidly in this case. Moreover, the long-axis division can result in more random cell orientations and more isotropic cell shapes within the monolayer, comparing with other two cases. This study helps understand the division orientation of cells within a monolayer under mechanical stimuli, and m...Continue Reading

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Citations

Oct 11, 2017·Mathematical Medicine and Biology : a Journal of the IMA·Alexander Nestor-BergmannOliver E Jensen
Jun 17, 2018·Physical Review. E·Alexander Nestor-BergmannOliver E Jensen
Nov 8, 2018·PloS One·Ying XinWinfried Just
Mar 27, 2021·Molecular Therapy. Nucleic Acids·Biqiang ZhuXiaohua Hou

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