Oriented Cell Divisions Are Not Required for Drosophila Wing Shape

Current Biology : CB
Zhenru ZhouKenneth D Irvine

Abstract

Formation of correctly shaped organs is vital for normal function. The Drosophila wing has an elongated shape, which has been attributed in part to a preferential orientation of mitotic spindles along the proximal-distal axis [1, 2]. Orientation of mitotic spindles is believed to be a fundamental morphogenetic mechanism in multicellular organisms [3-6]. A contribution of spindle orientation to wing shape was inferred from observations that mutation of Dachsous-Fat pathway genes results in both rounder wings and loss of the normal proximal-distal bias in spindle orientation [1, 2, 7]. To directly evaluate the potential contribution of spindle orientation to wing morphogenesis, we assessed the consequences of loss of the Drosophila NuMA homolog Mud, which interacts with the dynein complex and has a conserved role in spindle orientation [8, 9]. Loss of Mud randomizes spindle orientation but does not alter wing shape. Analysis of growth and cell dynamics in developing discs and in ex vivo culture suggests that the absence of oriented cell divisions is compensated for by an increased contribution of cell rearrangements to wing shape. Our results indicate that oriented cell divisions are not required for wing morphogenesis, nor are t...Continue Reading

Citations

Nov 16, 2019·Biomechanics and Modeling in Mechanobiology·Yasuhiro InoueTaiji Adachi
Feb 7, 2021·International Journal of Oral Science·Wei DuJimmy K Hu
Feb 23, 2020·Developmental Cell·Lara Barrio, Marco Milán
Sep 9, 2020·Current Opinion in Insect Science·Barry J Thompson
Jun 29, 2021·Current Opinion in Cell Biology·Rita MateusNatalie A Dye
Oct 2, 2021·Biology Open·Emily A Schiller, Dan T Bergstralh

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