Orientin improves depression-like behavior and BDNF in chronic stressed mice

Molecular Nutrition & Food Research
Yi LiuYinghua Yu

Abstract

Oxidative stress is involved in chronic stress-induced depression and the disruption of neurotransmission and neuroplasticity. Recently, orientin, a phenolic compound abundant in some fruits, millet, and herbs, has been shown to have antioxidant properties. This study investigated the potential antidepressant effects of orientin against chronic stress and its underlying mechanisms. The chronic unpredictable mild stress (CUMS) model was used to investigate the effects of orientin on behavior and biochemical alterations in mice. After 2 weeks of the CUMS protocol, the mice were treated with orientin (20 mg/kg and 40 mg/kg, oral gavage) for 3 weeks. Administration of orientin significantly alleviated the CUMS-induced depression-like behavior, including sucrose preference reduction, locomotor activity decline, and hypomotility. Orientin treatment attenuated the oxidative stress markers and increased the concentrations of serotonin and norepinephrine in the hippocampus and prefrontal cortex of CUMS mice. Orientin treatment also increased the brain-derived neurotrophic factor and synapse-associated proteins (synaptophysin and postsynaptic density protein 95) of CUMS mice. Orientin exerts antidepressant-like effects on CUMS mice, spec...Continue Reading

References

Jan 1, 1988·Free Radical Biology & Medicine·S GoldsteinG Czapski
Jun 1, 1966·The Biochemical Journal·E D Wills
Jan 1, 1984·Methods in Enzymology·H Aebi
Apr 5, 2002·Neuron·Eric J NestlerLisa M Monteggia
Oct 9, 2002·International Clinical Psychopharmacology·David J Nutt
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN
Nov 25, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Murray R ThompsonIain S McGregor
Jan 7, 2004·The Pharmacogenomics Journal·S RappJ Thome
Mar 11, 2005·Neurochemical Research·Fernanda U FontellaCarla Dalmaz
Mar 22, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Baiyi LuYing Zhang
May 7, 2005·Metabolism: Clinical and Experimental·Bruce S McEwen
Feb 25, 2006·Neurochemistry International·Luciane Rosa FeksaClovis Milton Duval Wannmacher
Jul 28, 2006·Journal of Psychiatric Research·Charles B Nemeroff
May 12, 2007·Toxicology·Victoria LinaresJosé L Domingo
Jan 22, 2008·Progress in Neurobiology·Kihoon Han, Eunjoon Kim
Feb 19, 2008·Current Opinion in Psychiatry·Gill van der WattAleksandar Janca
Jun 24, 2008·Phytotherapy Research : PTR·Qingqiu MaoChuntao Che
Oct 4, 2008·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Flávio KapczinskiRobert M Post
Nov 11, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Anteneh M FeyissaBeata Karolewicz
Jan 31, 2009·PloS One·Alessandro Bartolomucci, Rosario Leopardi
May 5, 2009·The Journal of Biological Chemistry·Melissa Brazier-HicksRobert Edwards
Oct 5, 2011·Reviews in the Neurosciences·Daniel J ChristoffelScott J Russo
Dec 4, 2012·Brain, Behavior, and Immunity·B J RawdinO M Wolkowitz
Dec 27, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·W N Marsden
Jan 8, 2013·Pharmacology, Biochemistry, and Behavior·Yi LiuXiaoxing Yin
Jan 30, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mario J SimirgiotisEdward J Kennelly

❮ Previous
Next ❯

Citations

Sep 24, 2015·Behavioural Brain Research·Shuting WangYi Liu
Jun 15, 2016·Advances in Pharmacological Sciences·Kit Ying LamYee How Say
Oct 30, 2016·Neuroscience Letters·Min-Wang ZhangFang Han
Jul 26, 2017·Scientific Reports·Zhi-Kun QiuDa-Nian Wei
Apr 7, 2018·Scientifica·León Jesús German-PoncianoJuan Francisco Rodríguez-Landa
Jun 28, 2019·Journal of Molecular Neuroscience : MN·Yi ZhongNing Jia
Aug 21, 2019·Oxidative Medicine and Cellular Longevity·José Rogério Souza-MonteiroMaria Elena Crespo-López
Jul 3, 2021·International Journal of Molecular Sciences·Martina TremmelJörg Heilmann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.