Orientin Reduces Myocardial Infarction Size via eNOS/NO Signaling and Thus Mitigates Adverse Cardiac Remodeling

Frontiers in Pharmacology
Fangfang LiWenhao Qian

Abstract

Orientin is a flavonoid extracted from Chinese traditional herb, Polygonum orientale L. Previous study has reported that orientin protected myocardial from ischemia reperfusion injury. However, whether orientin could protect against cardiac remodeling after myocardial injury remains unclear. The aim of our study is to investigate the effects of orientin in the progression of cardiac remodeling after myocardial infarction (MI). Mice cardiac remodeling model was established by left coronary artery ligation surgery. Experimental groups were as follows: vehicle-sham, orientin-sham, vehicle-MI, and orientin-MI. Animals were treated with vehicle or orientin (40 mg/kg) for 25 days starting 3 days after surgery. After 4 weeks of MI, mice with orientin treatment had decreased mortality and improved cardiac function. Significantly, at 4 weeks post-MI, orientin treatment decreased fibrosis, inflammatory response, and cardiomyocyte apoptosis. Furthermore, orientin treatment attenuated the hypoxia-induced neonatal rat cardiomyocyte apoptosis and increased cell viability. Additionally, orientin supplementation mitigated oxidative stress in remodeling heart tissue and cardiomyocytes exposed to hypoxia as measured by 2',7'-dichlorodihydrofluor...Continue Reading

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Citations

Sep 6, 2018·Food & Function·Carine Smith, Amanda Swart
Jul 22, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Minyi LinLigang Zhou
Feb 13, 2020·Pharmacological Reports : PR·Hima DhakalSang-Hyun Kim
Feb 23, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Omeed RahimiPatricia E Gallagher
Nov 17, 2020·Frontiers in Cardiovascular Medicine·Wei-Lu WangYi-Zhun Zhu

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