Orienting gaze shifts during muscimol inactivation of caudal fastigial nucleus in the cat. II. Dynamics and eye-head coupling

Journal of Neurophysiology
Laurent GoffartAlain Guillaume

Abstract

We have shown in the companion paper that muscimol injection in the caudal part of the fastigial nucleus (cFN) consistently leads to dysmetria of visually triggered gaze shifts that depends on movement direction. Based on the observations of a constant error and misdirected movements toward the inactivated side, we have proposed that the cFN contributes to the specification of the goal of the impending ipsiversive gaze shift. To test this hypothesis and also to better define the nature of the hypometria that affects contraversive gaze shifts, we report in this paper on various aspects of movement dynamics and of eye/head coordination patterns. Unilateral muscimol injection in cFN leads to a slight modification in the dynamics of both ipsiversive and contraversive gaze shifts (average velocity decrease = 55 degrees/s). This slowing in gaze displacements results from changes in both eye and head. In some experiments, a larger gaze velocity decrease is observed for ipsiversive gaze shifts as compared with contraversive ones, and this change is restricted to the deceleration phase. For two particular experiments testing the effect of visual feedback, we have observed a dramatic decrease in the velocity of ipsiversive gaze shifts af...Continue Reading

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Citations

Mar 11, 2003·Nature Neuroscience·André BergeronDaniel Guitton
Apr 14, 1999·Journal of Neurophysiology·J D CrawfordD Guitton
Jul 11, 2003·Journal of Neurophysiology·J F KleineU Buttner
Oct 17, 1998·Journal of Neurophysiology·M TakagiR J Tamargo
Oct 12, 2007·Journal of Neurophysiology·Julie Quinet, Laurent Goffart
May 15, 2009·Journal of Neurophysiology·Julie Quinet, Laurent Goffart
Sep 26, 2013·Journal of Computational Neuroscience·Pierre M DayePhilippe Lefèvre
Feb 23, 2020·The Journal of Comparative Neurology·Ted K DoykosGidon Felsen
May 9, 2006·Experimental Brain Research·Caroline TiliketeDenis Pélisson
Jan 27, 2019·Cerebellum & Ataxias·Kelsey JensenAasef G Shaikh
Mar 7, 2015·Journal of Neurophysiology·Julie Quinet, Laurent Goffart

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