Origanum vulgare L. Essential Oil as a Potential Anti-Acne Topical Nanoemulsion-In Vitro and In Vivo Study

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Mohammed H TalebMohammed A Ramadan

Abstract

Antibiotics are often prescribed in acne treatment; however, Propionibacterium acnes and Staphylococcus epidermidis, the two of the major acne-associated bacteria, developed antibiotic resistance. Essential oils (EOs) present a natural, safe, efficacious and multifunctional alternative treatment. This study aimed to assess the potential anti-acne activity of selected seven EOs commonly used in Mediterranean folk medicine. Antimicrobial activity screening of these oils showed oregano to exhibit the strongest antimicrobial activity with minimum inhibitory concentration (MIC) of 0.34 mg/mL and minimum bactericidal concentration (MBC) of 0.67 mg/mL against P. acnes; and MIC of 0.67 mg/mL and MBC of 1.34 mg/mL against S. epidermidis. The composition of the most effective EOs (oregano and thyme) was determined using gas chromatography-mass spectrometry (GC-MS). Monoterpenoid phenols predominated oregano and thyme EO with thymol percentile 99 and 72, respectively. Thymol showed MIC 0.70 mg/mL against both P. acnes and S. epidermidis whereas MBC was 1.40 and 2.80 mg/mL against P. acnes and S. epidermidis, respectively. Moreover, oregano exhibited the strongest anti-biofilm effect against S. epidermidis with MBIC 1.34 mg/mL and killing ...Continue Reading

References

Oct 15, 1990·The Medical Journal of Australia·I B BassettR S Barnetson
Jul 22, 1997·International Journal of Food Microbiology·B OuattaraA Bégin
Jul 13, 2004·International Journal of Food Microbiology·Sara Burt
Aug 23, 2005·Dermatologic Clinics·Peter R Hull, Carl D'Arcy
Feb 23, 2007·Indian Journal of Dermatology, Venereology and Leprology·Shahla EnshaiehFariba Iraji
Feb 5, 2008·Journal of Ethnopharmacology·M R González-TejeroS Eljohrig
Jun 5, 2010·Future Microbiology·Paul D Fey, Michael E Olson
Sep 17, 2010·Trends in Pharmacological Sciences·Liselotte Diaz HögbergOtto Cars
Feb 11, 2011·Journal of Visualized Experiments : JoVE·George A O'Toole
Sep 2, 2011·Lancet·Hywel C WilliamsSarah Garner
Sep 10, 2011·Current Opinion in Biotechnology·Fortino Solórzano-Santos, Maria Guadalupe Miranda-Novales
Jan 14, 2012·Nature Protocols·Jackson LiangYao LiLai Guan Ng
Jul 13, 2012·Natural Product Reports·Ana Cristina AbreuManuel Simões
Sep 18, 2012·Journal of Colloid and Interface Science·Felix OstertagDavid Julian McClements
May 3, 2014·Drug Delivery·Abhishek Budhiraja, Garima Dhingra
Aug 26, 2014·BioMed Research International·Priyam SinhaNarayan Prasad Yadav
Jun 18, 2015·Annals of Dermatology·Yong Hyun JangWeon Ju Lee
Jan 4, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Javad Sharifi-RadMarcello Iriti
Sep 5, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hazem S ElshafieIppolito Camele
Dec 13, 2017·BioMed Research International·Hazem S Elshafie, Ippolito Camele

❮ Previous
Next ❯

Citations

Mar 27, 2020·Clinical, Cosmetic and Investigational Dermatology·Vittorio MazzarelloMaria Antonia Montesu
Jan 9, 2021·Journal of Animal Science and Biotechnology·Bocheng XuYizhen Wang
Dec 23, 2020·International Journal of Molecular Sciences·Adelina LombreaCorina Danciu
Feb 18, 2020·International Journal of Pharmaceutics·Rinaldo Patel, Priyanka Prabhu
Nov 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Krassimira YonchevaHristo M Najdenski

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

Graph Pad Prism
Excel
AMDIS

Related Concepts

Related Feeds

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.

Biofilms

Biofilms are adherent bacterial communities embedded in a polymer matrix and can cause persistent human infections that are highly resistant to antibiotics. Discover the latest research on Biofilms here.