PMID: 7512063Mar 1, 1994Paper

Origin and development of exocrine pancreatic insufficiency in experimental renal failure

Gut
M M LerchW Gerok

Abstract

Chronic renal failure affects the physiological function of many organ systems. One of them is the exocrine pancreas. Although varying degrees of pancreatic insufficiency are the dominating clinical characteristic of uraemic pancreatic disease, it remains unclear whether this disease should be regarded as a manifestation of chronic pancreatitis, arising from recurring attacks of acute pancreatitis, or represents a distinct entity. The exocrine pancreas was studied in a model of experimental renal failure. The pancreas was removed from each rat at selected time points over eight weeks after subtotal nephrectomy and from a standard rat model of pancreatitis for comparison. The data show that the in vitro secretory response is considerably changed in renal failure (increased during early acute and decreased during chronic renal failure). While the pancreatic content of digestive enzymes progressively declines, DNA and protein synthesis increase over time. Acinar cell deletion is increased and accompanied by an increased rate of mitosis. This increased cellular turnover is not associated with tissue oedema, pancreatic fibrosis, inflammatory changes, autophagocytosis or subcellular redistribution of lysosomal hydrolases, all of whic...Continue Reading

References

May 1, 1976·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·G Wagner, S Hollman
Sep 1, 1977·Experimentelle Pathologie·H P PutzkeA Bienengräber
Aug 1, 1978·Archives of Internal Medicine·C G BarcenasA R Hull
Aug 1, 1985·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A López-De León, M Rojkind
Sep 1, 1989·Digestive Diseases and Sciences·T ArakiK Kosaka
Jan 1, 1989·Gastrointestinal Radiology·M M LerchS Matern
Aug 1, 1986·Radiology·J A Van DykeR J Stanley
Apr 1, 1987·European Journal of Biochemistry·P J PlompP O Seglen
Mar 1, 1980·Analytical Biochemistry·C Labarca, K Paigen
Nov 1, 1982·Digestive Diseases and Sciences·G AdlerH F Kern
Feb 1, 1962·The Journal of Cell Biology·L HERMAN, P J FITZGERALD
Feb 1, 1948·American Journal of Obstetrics and Gynecology·R R SURAN, P C MEISTER
Jan 1, 1948·American Journal of Obstetrics and Gynecology·C F FLUHMANN

Citations

Dec 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·A M Ravelli
May 1, 1999·The Pediatric Infectious Disease Journal·C N Edwards
Jul 18, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Peter SimonM M Lerch
Apr 25, 2006·Endocrinology and Metabolism Clinics of North America·M M LerchJulia Mayerle
Aug 19, 2007·The Journal of Small Animal Practice·P J WatsonM E Herrtage
Jun 12, 2019·International Journal of Molecular Sciences·Pedro Silva-VazJosé Guilherme Tralhão
Jan 22, 2021·Orphanet Journal of Rare Diseases·Woo Jin HwangSook-Za Kim

Related Concepts

Amylases
DNA, Double-Stranded
Kidney Failure, Chronic
Exolipase
S-Phase Fraction
Pancreas
Exocrine Pancreatic Insufficiency
Pancreatitis
Protein Biosynthesis
Rats, Holtzman

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