Origin and development of neuropil glia of the Drosophila larval and adult brain: Two distinct glial populations derived from separate progenitors

Developmental Biology
Jaison J OmotoVolker Hartenstein

Abstract

Glia comprise a conspicuous population of non-neuronal cells in vertebrate and invertebrate nervous systems. Drosophila serves as a favorable model to elucidate basic principles of glial biology in vivo. The Drosophila neuropil glia (NPG), subdivided into astrocyte-like (ALG) and ensheathing glia (EG), extend reticular processes which associate with synapses and sheath-like processes which surround neuropil compartments, respectively. In this paper we characterize the development of NPG throughout fly brain development. We find that differentiated neuropil glia of the larval brain originate as a cluster of precursors derived from embryonic progenitors located in the basal brain. These precursors undergo a characteristic migration to spread over the neuropil surface while specifying/differentiating into primary ALG and EG. Embryonically-derived primary NPG are large cells which are few in number, and occupy relatively stereotyped positions around the larval neuropil surface. During metamorphosis, primary NPG undergo cell death. Neuropil glia of the adult (secondary NPG) are derived from type II lineages during the postembryonic phase of neurogliogenesis. These secondary NPG are much smaller in size but greater in number than pri...Continue Reading

References

Apr 1, 1986·The Journal of Comparative Neurology·G HoyleC Phillips
Apr 1, 1986·The Journal of Comparative Neurology·G Hoyle
Nov 27, 1998·The Journal of Comparative Neurology·V HartensteinA Lekven
Aug 25, 1999·Cell and Tissue Research·L A OlandI Burger
Jul 2, 2003·Development·Rolf Urbach, Gerhard M Technau
Oct 22, 2003·Developmental Biology·Ting ChangVolker Hartenstein
May 29, 2004·The EMBO Journal·Rachel L Griffiths, Alicia Hidalgo
May 24, 2005·Developmental Biology·Wayne PereanuVolker Hartenstein
May 19, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wayne Pereanu, Volker Hartenstein
Jul 27, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Laurent Soustelle, Angela Giangrande
Dec 11, 2007·Nature Neuroscience·Yael GrosjeanDavid E Featherstone
Jan 18, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tobias StorkChristian Klämbt
Feb 26, 2008·Mechanisms of Development·Ruth M BeckervordersandforthGerhard M Technau
May 1, 2008·Developmental Neurobiology·Weitao Chen, Huey Hing
Jun 10, 2008·The Journal of Comparative Neurology·Lynne A OlandLeslie P Tolbert
Dec 19, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Takeshi AwasakiTzumin Lee
Apr 17, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Johnna DohertyMarc R Freeman
Aug 28, 2009·The Journal of Comparative Neurology·Abhilasha KumarVolker Hartenstein
Sep 19, 2009·Development·Abhilasha KumarHeinrich Reichert
Dec 17, 2009·Neural Development·Natalya IzerginaHeinrich Reichert
Jan 30, 2010·Progress in Neurobiology·Tara N Edwards, Ian A Meinertzhagen
Apr 8, 2010·Neural Development·Irina SinakevitchSerge Birman
Jun 10, 2010·The Journal of Comparative Neurology·Wayne PereanuVolker Hartenstein
Oct 29, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stephanie M StaceyDonald J van Meyel
May 18, 2011·Glia·Daniel K Hartline
Nov 10, 2011·Development·B V V G Reddy, Kenneth D Irvine
Jan 5, 2012·Genes & Development·Yingdee Unhavaithaya, Terry L Orr-Weaver
Jun 23, 2012·PloS One·Albert CardonaRodney J Douglas
Jun 30, 2012·Nature Methods·Johannes SchindelinAlbert Cardona
Apr 2, 2013·Current Biology : CB·Hung-Hsiang YuTzumin Lee
Dec 24, 2013·Genes & Development·Ozge E Tasdemir-Yilmaz, Marc R Freeman
Jan 28, 2014·PloS One·Yaniv HakimOren Schuldiner

❮ Previous
Next ❯

Citations

Jul 17, 2015·Wiley Interdisciplinary Reviews. Developmental Biology·Sofia SasseChristian Klämbt
Jan 31, 2017·Glia·Malte C KremerUlrike Gaul
Apr 8, 2017·Developmental Neurobiology·Aswati SubramanianJoyce Fernandes
Aug 10, 2017·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Kentaro KatoAlicia Hidalgo
Nov 3, 2016·Development·Ting-Hao HuangCarlos Lois
Mar 23, 2017·The EMBO Journal·Lynette Caizhen FooStephen Michael Cohen
Jul 5, 2017·The Journal of Comparative Neurology·Jennifer K LovickVolker Hartenstein
Jul 22, 2017·The Journal of Comparative Neurology·Volker HartensteinAmelia Younossi-Hartenstein
Feb 26, 2020·Developmental Neurobiology·Jonas BitternChristian Klämbt
Nov 18, 2018·Glia·Kerem YildirimChristian Klämbt
Jul 15, 2020·International Journal of Molecular Sciences·Taejoon KimIm-Soon Lee
Jan 7, 2021·Cell and Tissue Research·Vanessa M PuñalE Josephine Clowney
Oct 17, 2020·Current Opinion in Insect Science·Gyunghee Lee, Jae H Park

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Astrocytes in Repair & Regeneration

Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis