Feb 10, 2012

Origin and evolution of laminin gene family diversity

Molecular Biology and Evolution
Bryony Fahey, Bernard M Degnan

Abstract

Laminins are a family of multidomain glycoproteins that are important contributors to the structure of metazoan extracellular matrices. To investigate the origin and evolution of the laminin family, we characterized the full complement of laminin-related genes in the genome of the sponge, Amphimedon queenslandica. As a representative of the Demospongiae, a group consistently placed within the earliest diverging branch of animals by molecular phylogenies, Amphimedon is uniquely placed to provide insight into early steps in the evolution of metazoan gene families. Five Amphimedon laminin-related genes possess the conserved molecular features, and most of the domains found in bilaterian laminins, but all display domain architectures distinct from those of the canonical laminin chain types known from model bilaterians. This finding prompted us to perform a comparative genomic analysis of laminins and related genes from a choanoflagellate and diverse metazoans and to conduct phylogenetic analyses using the conserved Laminin N-terminal domain in order to explore the relationships between genes with distinct architectures. Laminin-like genes appear to have originated in the holozoan lineage (choanoflagellates + metazoans + several oth...Continue Reading

  • References43
  • Citations15

Mentioned in this Paper

Complement System Proteins
Glycoproteins
Nematostella vectensis
Extracellular Matrix
Tertiary Protein Structure
Ctenophora
Placozoa
Demospongiae
Phylogeny
Cnidaria

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