Jun 4, 2014

Profiling anti-apoptotic protein BCL-xL expression in U-87 MG glioblastoma cells and patient-derived tumorspheres

BioRxiv : the Preprint Server for Biology
Gáspár JékelyGabriel Ichim


Glioblastoma is one of the cancers with the worst prognosis, despite huge efforts to understand its unusual heterogeneity and aggressiveness. These are mainly attributable to glioblastoma stem cells, which are also responsible for the frequent tumour recurrence following surgery or chemo/radiotherapy. We report here that tumorspheres derived from the U-87 MG glioblastoma cells have an increased expression of the anti-apoptotic protein BCL-xL. Modulation of this expression in tumorspheres enlightened us on the potential role of apoptosis and BCL-2 proteins might play in the survival of glioblastoma stem cells. Moreover, increased BCL-xL expression appears to sensitise glioblastoma cells to the newly developed BH3 mimetics, opening new therapeutic perspectives for treating glioblastoma patients.

  • References
  • Citations


  • We're still populating references for this paper, please check back later.
  • References
  • Citations


  • This paper may not have been cited yet.

Mentioned in this Paper

Molecular Motor Activity
Cell Motility
Filamentous fungus
Ciliary Body
Organellar Ribosome
Comparative Genomic Analysis
Cytoskeletal Filaments

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.