PMID: 6974216Sep 1, 1981Paper

Origin and fate of IgE-bearing lymphocytes. I. Peyer's patches as differentiation site of cells. Simultaneously bearing IgA and IgE

The Journal of Experimental Medicine
H G DurkinB H Waksman

Abstract

Peyer's patches (PP) from adult conventionally raised (C) and germ-free (GF) rats of the same age differed strikingly in the distributions of cells bearing membrane-bound immunoglobulin of the different isotypes. High concentrations of cells with membrane-bound IgE (approximately 20% of total cells determined by indirect immunofluorescence) were found in PP of rats, whereas IgE+ cells were absent from PP of C rats. The numbers of IgA+ cells were almost threefold higher in PP of GF rats when compared with C rats. In contrast, PP of GF rats had greatly reduced numbers of IgM-bearing cells (4%) when compared with C rats (23%); in some experiments virtually no IgM-bearing cells were detected. The levels of IgA- and IgE-bearing cells in spleen of GF rats were increased (to 11% and 7%, respectively). Of the IgE-bearing cells in PP and spleen of GF rats, approximately one-half were simultaneously positive for IgA. When these PP cells were treated with pronase to remove membrane bound immunoglobulins and maintained in culture, both IgE and IgA reappeared within 12 h. The proportion of doubly labeled cells was similar to that of the untreated population. No IgE+ cells were detected in bone marrow of C of GF rats at any time, in agreemen...Continue Reading

References

Jan 1, 1978·Immunological Reviews·K Ishizaka, T Ishizaka
Mar 1, 1974·The Journal of Experimental Medicine·P P JonesL A Herzenberg
Jan 1, 1969·International Archives of Allergy and Applied Immunology·O Strannegård, A Yurchision

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Citations

Mar 3, 2010·Annual Review of Immunology·David A Hill, David Artis
Jan 1, 1985·Scandinavian Journal of Gastroenterology. Supplement·P Brandtzaeg
Jun 30, 1983·Annals of the New York Academy of Sciences·B H Waksman
Jan 1, 1987·Scandinavian Journal of Infectious Diseases. Supplementum·H Schønheyder
Jan 7, 2015·Pharmacology & Therapeutics·Giovanni CammarotaDiego Currò
Jul 4, 2012·Journal of Bioscience and Bioengineering·Takashi SatohHirokuni Miyamoto
Jul 1, 1984·The American Journal of Anatomy·J Bienenstock, D Befus
May 1, 1989·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·J S MarshallP B Ernst
Jan 24, 2019·Gut·Maria Gloria Dominguez-BelloMartin J Blaser
Aug 14, 2015·World Journal of Gastroenterology : WJG·Sai Manasa JandhyalaD Nageshwar Reddy
Apr 14, 2017·Physiology·Sarah GallaBina Joe
Feb 8, 2014·Gastroenterology·Nobuhiko Kamada, Gabriel Núñez
Mar 6, 1999·Clinical and Diagnostic Laboratory Immunology·H YasuiK Shida

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