PMID: 29779015DOI: 10.18632/aging.101450May 21, 2018Paper
Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging
Aging
Efstathios S GonosIzabela Sadowska-Bartosz
Abstract
Non-enzymatic protein modifications occur inevitably in all living systems. Products of such modifications accumulate during aging of cells and organisms and may contribute to their age-related functional deterioration. This review presents the formation of irreversible protein modifications such as carbonylation, nitration and chlorination, modifications by 4-hydroxynonenal, removal of modified proteins and accumulation of these protein modifications during aging of humans and model organisms, and their enhanced accumulation in age-related brain diseases.
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Methods Mentioned
BETA
MDA
carbonylation
electrophoresis
ELISA
deubiquitination
ubiquitination
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