Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging

Aging
Efstathios S GonosIzabela Sadowska-Bartosz

Abstract

Non-enzymatic protein modifications occur inevitably in all living systems. Products of such modifications accumulate during aging of cells and organisms and may contribute to their age-related functional deterioration. This review presents the formation of irreversible protein modifications such as carbonylation, nitration and chlorination, modifications by 4-hydroxynonenal, removal of modified proteins and accumulation of these protein modifications during aging of humans and model organisms, and their enhanced accumulation in age-related brain diseases.

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Citations

Jun 20, 2019·Journal of Clinical Medicine·Anna KlimiukAnna Zalewska
Jan 9, 2020·The International Journal of Neuroscience·Maria Bandookwala, Pinaki Sengupta
Dec 31, 2019·Oxidative Medicine and Cellular Longevity·Mateusz MaciejczykJerzy Robert Ładny
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Jun 27, 2019·Chemistry : a European Journal·Yuxin LiuJianguo Fang
Feb 20, 2021·Critical Reviews in Toxicology·Thilona ArumugamAnil A Chuturgoon
Mar 30, 2021·Environmental Research·Periklis VardakasDemetrios Kouretas
Apr 4, 2021·International Journal of Molecular Sciences·Fabiano CimminoMaria Pina Mollica
Jul 22, 2021·Photodiagnosis and Photodynamic Therapy·Ana Flavia Gatto RaimundoRodrigo Polimeni Constantin
Dec 28, 2021·IUBMB Life·Marianna KapetanouEfstathios S Gonos

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Methods Mentioned

BETA
MDA
carbonylation
electrophoresis
ELISA
deubiquitination
ubiquitination

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