PMID: 6111353Jan 26, 1981Paper

Origin and pattern of glucocorticoid-induced hyperlipidemia in rats. Dose-dependent bimodal changes in serum lipids and lipoproteins in relation to hepatic lipogenesis and tissue lipoprotein lipase activity

Biochimica Et Biophysica Acta
Y KrauszE Shafrir

Abstract

Rats maintained for five days on a low dose of triamcinolone (0.5 mg/kg) showed a 2-fold increase in serum triacylglycerol concentration, paralleled by a rise in all very low density lipoprotein (VLDL) components but no significant change in serum cholesterol or high density lipoproteins (HDL). In contrast, a high dose of triamcinolone (12.5 mg/kg) produced a fall in triacylglycerol and VLDL to the range of control levels coincident with doubling in serum cholesterol and HDL. The rise in VLDL was attributed in a large part to enhanced hepatic fatty acid synthesis as evident from the marked rises in activity of rate-limiting enzymes of lipogenesis and in 3H incorporation into liver and serum fatty acids from in vivo administered 3H2O. The induction of fatty acid synthesis was linked to pronounced hyperinsulinemia, elicited by the triamcinolone treatment, to which the liver remained selectively responsive, contrary to the general insulin antagonism in peripheral tissues. Triamcinolone treatment also resulted in small rises in serum glucagon but these changes did not appear to be of importance for the observed bimodal serum lipoprotein perturbations. Dexamethasone, prednisolone and cortisol, administered in doses equipotent to 0.5...Continue Reading

References

Jun 1, 1976·Diabetes·H Bar-OnH A Eder
Oct 1, 1977·The Journal of Clinical Investigation·C B BlumM Berman
May 6, 1975·European Journal of Biochemistry·S Diamant, E Shafrir
Dec 5, 1968·European Journal of Biochemistry·H de Wulf, H G Hers
Nov 1, 1973·The Journal of Clinical Investigation·J K WiseP Felig
Jun 1, 1967·The American Journal of Physiology·H Klausner, M Heimberg
Oct 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·W Kreutner, N D Goldberg
Jul 1, 1970·Analytical Biochemistry·R J Ho
Sep 1, 1955·The Journal of Clinical Investigation·R J HAVELJ H BRAGDON
Oct 1, 1955·The Journal of Clinical Endocrinology and Metabolism·C I WANGD ADLERSBERG
Nov 1, 1957·The American Journal of Medicine·D ADLERSBERG
Jan 1, 1960·Scandinavian Journal of Clinical and Laboratory Investigation·E RAABO, T C TERKILDSEN
Jul 1, 1963·The Biochemical Journal·C N HALES, P J RANDLE
Jan 1, 1965·The American Journal of Physiology·M FRIEDMANS STGEORGE
Jun 1, 1965·Experimental and Molecular Pathology·R B HILLA P HAYS
Nov 11, 1950·Journal of the American Medical Association·D ADLERSBERGS R DRACHMAN

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Citations

Jan 1, 1989·International Urology and Nephrology·L KuzemkováK Matousovic
Feb 1, 1987·Atherosclerosis·W H EttingerP O Kwiterovitch
Jan 1, 1994·Molecular Aspects of Medicine·G Desoye, E Shafrir
Mar 26, 2013·Molecular and Cellular Endocrinology·Adam J Rose, Stephan Herzig
May 2, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Albert SalazarRamon Pujol
Feb 23, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Adam J RoseStephan Herzig
Jul 13, 2007·Molecular and Cellular Endocrinology·Alexandros Vegiopoulos, Stephan Herzig
Nov 1, 1988·Metabolism: Clinical and Experimental·W H Ettinger, W R Hazzard
Nov 1, 1985·Metabolism: Clinical and Experimental·M G BaggenJ C Birkenhäger
Aug 1, 1991·The American Journal of Cardiology·J S StamlerJ Loscalzo
Sep 1, 1987·The American Journal of Medicine·W H EttingerW R Hazzard
Apr 22, 2017·The Journal of Endocrinology·Caroline E Geisler, Benjamin J Renquist
Oct 27, 1998·The Journal of Pediatrics·J R FerrarisT Pasqualini
Oct 10, 2015·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Carolyn CrayGregory D Bossart
Sep 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·C N WangD N Brindley
May 8, 2020·Molecular Nutrition & Food Research·Danijela Vojnović MilutinovićNataša Veličković
Jan 22, 2011·Circulation Research·Ellen Neven, Patrick C D'Haese
May 6, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Leili RahimiFaramarz Ismail-Beigi
May 1, 1983·The American Journal of Physiology·B KalderonA Gutman
Aug 7, 2020·Diabetes & Metabolic Syndrome·Roldan M de Guia
Jan 20, 1994·Biochimica Et Biophysica Acta·H YamashitaT Shimazu

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