Origin and phylogenetic relationships of [4Fe-4S]-containing O2 sensors of bacteria

Environmental Microbiology
C BarthG Unden

Abstract

The advent of environmental O2 about 2.5 billion years ago forced microbes to metabolically adapt and to develop mechanisms for O2 sensing. Sensing of O2 by [4Fe-4S]2+ to [2Fe-2S]2+ cluster conversion represents an ancient mechanism that is used by FNREc (Escherichia coli), FNRBs (Bacillus subtilis), NreBSa (Staphylococcus aureus) and WhiB3Mt (Mycobacterium tuberculosis). The phylogenetic relationship of these sensors was investigated. FNREc homologues are restricted to the proteobacteria and a few representatives from other phyla. Homologues of FNRBs and NreBSa are located within the bacilli, of WhiB3 within the actinobacteria. Archaea contain no homologues. The data reveal no similarity between the FNREc , FNRBs , NreBSa and WhiB3 sensor families on the sequence and structural levels. These O2 sensor families arose independently in phyla that were already present at the time O2 appeared, their members were subsequently distributed by lateral gene transfer. The chemistry of [4Fe-4S] and [2Fe-2S] cluster formation and interconversion appears to be shared by the sensor protein families. The type of signal output is, however, family specific. The homologues of FNREc and NreBSa vary with regard to the number of Cys residues that c...Continue Reading

References

Jan 1, 1992·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·T A RouaultJ B Harford
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S KaptainR D Klausner
Aug 1, 1990·Journal of Bacteriology·J I MacInnesG A Soltes
Nov 15, 1974·Molecular and Cellular Biochemistry·W A Engelhardt
May 15, 1983·Journal of Molecular Biology·D J ShawJ R Guest
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·N KhoroshilovaP J Kiley
Jan 1, 1994·Antonie van Leeuwenhoek·J Batut, P Boistard
Apr 1, 1993·Molecular Microbiology·J GreenJ R Guest
Jul 1, 1996·Journal of Bacteriology·M LaCelleM M Nakano
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·N KhoroshilovaP J Kiley
Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Dec 11, 1997·Journal of Bacteriology·J H Zeilstra-RyallsR G Kranz
Apr 16, 1998·Microbiology·Dominic O GostickJohn R Guest
Feb 17, 1999·FEMS Microbiology Reviews·P J Kiley, H Beinert
Apr 5, 2000·Biochemistry·S Ollagnier-De ChoudensM Fontecave
May 29, 2000·Trends in Genetics : TIG·P RiceA Bleasby
Jun 16, 2001·Advances in Microbial Physiology·J GreenJ R Guest
Nov 7, 1996·Chemical Reviews·Helmut BeinertC. David Stout

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.