Origin and Possible Genetic Recombination of the Middle East Respiratory Syndrome Coronavirus from the First Imported Case in China: Phylogenetics and Coalescence Analysis

MBio
Yanqun WangWenjie Tan

Abstract

The Middle East respiratory syndrome coronavirus (MERS-CoV) causes a severe acute respiratory tract infection with a high fatality rate in humans. Coronaviruses are capable of infecting multiple species and can evolve rapidly through recombination events. Here, we report the complete genomic sequence analysis of a MERS-CoV strain imported to China from South Korea. The imported virus, provisionally named ChinaGD01, belongs to group 3 in clade B in the whole-genome phylogenetic tree and also has a similar tree topology structure in the open reading frame 1a and -b (ORF1ab) gene segment but clusters with group 5 of clade B in the tree constructed using the S gene. Genetic recombination analysis and lineage-specific single-nucleotide polymorphism (SNP) comparison suggest that the imported virus is a recombinant comprising group 3 and group 5 elements. The time-resolved phylogenetic estimation indicates that the recombination event likely occurred in the second half of 2014. Genetic recombination events between group 3 and group 5 of clade B may have implications for the transmissibility of the virus. The recent outbreak of MERS-CoV in South Korea has attracted global media attention due to the speed of spread and onward transmissi...Continue Reading

References

Jul 16, 2004·Journal of Virology·Alexander E GorbalenyaWilly J M Spaan
Aug 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Boyd YountRalph S Baric
Mar 1, 2012·Molecular Biology and Evolution·Alexei J DrummondAndrew Rambaut
Oct 9, 2012·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·V M CormanC Drosten
Oct 19, 2012·The New England Journal of Medicine·Ali M ZakiRon A M Fouchier
Nov 12, 2013·Emerging Infectious Diseases·Ziad A MemishW Ian Lipkin
Dec 21, 2013·The Lancet Infectious Diseases·Bart L HaagmansMarion P G Koopmans
Jan 17, 2015·The Lancet. Respiratory Medicine·Alimuddin ZumlaDavid S Hui
Mar 27, 2015·Emerging Infectious Diseases·Maged G HemidaMalik Peiris
May 24, 2015·Paediatric Respiratory Reviews·G R BanikH Rashid
Jun 8, 2015·Lancet·Alimuddin ZumlaStanley Perlman
Jun 9, 2015·The Lancet. Respiratory Medicine·David S HuiAlimuddin Zumla
May 1, 2015·Future Virology·Michael Edelstein, David L Heymann

❮ Previous
Next ❯

Citations

Dec 29, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Mika ItoMakoto Nagai
Jan 28, 2016·Emerging Infectious Diseases·Moon-Woo SeongSung Sup Park
Mar 26, 2016·Trends in Microbiology·Shuo SuGeorge F Gao
Jun 21, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Alimuddin ZumlaEskild Petersen
Jun 16, 2016·The Journal of Infectious Diseases·Abdullah M AssiriSusan I Gerber
Sep 28, 2016·PLoS Pathogens·Canping HuangGeorge F Gao
Dec 13, 2016·Expert Opinion on Therapeutic Targets·Lanying DuShibo Jiang
Oct 17, 2017·International Journal of Molecular Sciences·Susanna K P LauPatrick C Y Woo
Dec 3, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·William J LiuWenjie Tan
Sep 1, 2017·Journal of Medical Microbiology·Ali A RabaanHatem M Alhani
Nov 6, 2015·Journal of Korean Medical Science·Myoung-Don OhNam Joong Kim
Jan 1, 2019·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Khalid H AlanaziJohn T Watson
Jun 14, 2018·Frontiers in Microbiology·Pei HuangXianzhu Xia
May 14, 2017·Frontiers of Medicine·Ali A RabaanJaffar A Al-Tawfiq
Dec 3, 2016·Cold Spring Harbor Molecular Case Studies·Donghyun ParkWoong-Yang Park
Aug 23, 2017·Expert Review of Respiratory Medicine·Ali A Rabaan
Dec 2, 2020·Emerging Topics in Life Sciences·Ny Anjara Fifi RavelomanantsoaCara E Brook
Dec 18, 2020·PLoS Genetics·Louis-Marie BobayHoward Ochman
Sep 11, 2019·Veterinary Microbiology·Zhaozhong ZhuYousong Peng
Jan 20, 2021·Annals of Clinical Microbiology and Antimicrobials·Ali A RabaanAlfonso J Rodriguez-Morales
May 2, 2021·Virology Journal·Mohamed A FarragFahad N Almajhdi
Dec 1, 2021·Archives of Virology·Iman Safari, Elahe Elahi

❮ Previous
Next ❯

Methods Mentioned

BETA
reverse transcription PCR

Software Mentioned

RAxML
CLC Genomic Workbench
BEAST
SimPlot

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.