Origin and structure of the group-specific, complement-fixing antigen of Rickettsia rickettsii.

Applied Microbiology
T TzianabosM L Martin

Abstract

Rickettsia rickettsii was treated with ether and examined by negative-contrast electron microscopy. Group-specific complement-fixing antigen was seen to be originating from the cell wall. The antigen was composed predominately of round particles 10 to 60 nm in diameter. Intact R. rickettsii and antigen from ether-treated organisms were purified by density gradient centrifugation and analyzed by polyacrylamide gel electrophoresis. The whole rickettsial cell was composed of a minimum of 30 proteins which ranged in molecular weight from about 23,000 to 155,000. The "soluble" antigen contained nine proteins ranging in molecular weight from about 28,000 to 150,000.

References

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Citations

Sep 1, 1978·Infection and Immunity·J V Osterman, C S Eisemann
Aug 1, 1978·Journal of Clinical Microbiology·J V Osterman, C S Eisemann
Aug 1, 1980·Infection and Immunity·D K Smith, H H Winkler
Nov 1, 1984·Infection and Immunity·J V Lange, D H Walker
Jul 1, 1976·Infection and Immunity·C S Eisemann, J V Osterman

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