Origin of axial prestretch and residual stress in arteries.

Biomechanics and Modeling in Mechanobiology
L CardamoneJ D Humphrey

Abstract

The structural protein elastin endows large arteries with unique biological functionality and mechanical integrity, hence its disorganization, fragmentation, or degradation can have important consequences on the progression and treatment of vascular diseases. There is, therefore, a need in arterial mechanics to move from materially uniform, phenomenological, constitutive relations for the wall to those that account for separate contributions of the primary structural constituents: elastin, fibrillar collagens, smooth muscle, and amorphous matrix. In this paper, we employ a recently proposed constrained mixture model of the arterial wall and show that prestretched elastin contributes significantly to both the retraction of arteries that is observed upon transection and the opening angle that follows the introduction of a radial cut in an unloaded segment. We also show that the transmural distributions of elastin and collagen, compressive stiffness of collagen, and smooth muscle tone play complementary roles. Axial prestresses and residual stresses in arteries contribute to the homeostatic state of stress in vivo as well as adaptations to perturbed loads, disease, or injury. Understanding better the development of and changes in ...Continue Reading

References

Jun 1, 1977·Biopolymers·K L Dorrington, N G McCrum
Sep 1, 1975·Journal of Biomechanics·R H Cox
Jan 1, 1991·Annals of Biomedical Engineering·Y C Fung
Jan 1, 1991·Annals of the New York Academy of Sciences·S T CrookeC F Bennett
Feb 1, 1990·The Journal of Surgical Research·P B DobrinR Mrkvicka
Nov 1, 1989·Journal of Biomechanical Engineering·E Nevo, Y Lanir
May 1, 1986·Journal of Biomechanical Engineering·C J Chuong, Y C Fung
Sep 1, 1967·Biorheology·E G Tickner, A H Sacks
Dec 1, 1966·Circulation Research·D J Patel, D L Fry
Nov 1, 1995·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·E C Davis
Nov 1, 1995·Journal of Vascular Research·A SainiS Greenwald
Jul 1, 1996·Canadian Journal of Physiology and Pharmacology·B L Langille
Nov 1, 1996·Journal of Biomechanical Engineering·A Badreck-AmoudiS E Greenwald
Jan 4, 1998·Journal of Biomechanical Engineering·S E GreenwaldJ J Meister
Jun 16, 2001·Journal of Vascular Research·N StergiopulosS E Greenwald
Jan 11, 2002·Journal of Biomechanical Engineering·L A Taber, J D Humphrey
May 4, 2002·Nature Reviews. Molecular Cell Biology·James J TomasekRobert A Brown
May 22, 2002·Journal of Biomechanics·Martin A ZulligerNikolaos Stergiopulos
Jun 28, 2002·Annals of Biomedical Engineering·J D Humphrey, S Na
Aug 22, 2002·Journal of Biomechanical Engineering·Timothy J Van Dyke, Anne Hoger
Apr 16, 2003·Journal of Biomechanics·A Rachev, S E Greenwald
Jul 8, 2003·The Journal of Physiology·Ana M BrionesSilvia M Arribas
Oct 31, 2003·Biomechanics and Modeling in Mechanobiology·J D Humphrey, K R Rajagopal
Feb 10, 2004·Biomechanics and Modeling in Mechanobiology·J StålhandM Karlsson
Sep 3, 2004·Journal of Biomechanical Engineering·R L GleasonJ D Humphrey
Mar 31, 2005·Journal of Biomechanical Engineering·R L GleasonJ D Humphrey
Apr 20, 2005·Advances in Protein Chemistry·Suzanne M Mithieux, Anthony S Weiss
Feb 21, 2006·Pharmacology & Therapeutics·Silvia M ArribasM Carmen González
Mar 15, 2006·Journal of Biomechanical Engineering·S BaekJ D Humphrey
May 1, 1961·The Journal of Physiology·D H Bergel
Jan 24, 2007·American Journal of Physiology. Heart and Circulatory Physiology·E FonckN Stergiopulos
Feb 8, 2007·Annals of Biomedical Engineering·Gerhard A HolzapfelRay W Ogden
Jul 20, 2007·Annals of Biomedical Engineering·Victor AlastruéManuel Doblaré
Sep 6, 2007·Biomechanics and Modeling in Mechanobiology·Patrick W AlfordLarry A Taber
Dec 25, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Evren U AzelogluKevin D Costa
Jan 30, 2008·Birth Defects Research. Part C, Embryo Today : Reviews·Jessica E Wagenseil, Robert P Mecham
Jul 24, 2008·Journal of the Royal Society, Interface·A ValentínJ D Humphrey
Aug 8, 2008·Journal of Biomechanics·Ingrid MassonMustapha Zidi
Feb 21, 2009·Computer Methods in Biomechanics and Biomedical Engineering·B K WickerJ D Humphrey

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Citations

Nov 28, 2009·Biomechanics and Modeling in Mechanobiology·H SchmidM Itskov
Jan 6, 2011·Biomechanics and Modeling in Mechanobiology·Ingrid MassonMustapha Zidi
Aug 4, 2009·Medical & Biological Engineering & Computing·Arturo Valentín, Jay D Humphrey
Aug 27, 2013·Journal of the Mechanics and Physics of Solids·Manuel K Rausch, Ellen Kuhl
May 21, 2010·Mathematical Medicine and Biology : a Journal of the IMA·L CardamoneJ D Humphrey
Jul 9, 2009·Journal of Hypertension·John F EberthJay D Humphrey
Oct 16, 2009·Journal of the Royal Society, Interface·Gerhard A Holzapfel, Ray W Ogden
Jul 28, 2010·Journal of the Royal Society, Interface·J FerruzziJ D Humphrey
Aug 7, 2009·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·A Valentín, J D Humphrey
Oct 17, 2009·Journal of Biomechanical Engineering·A Valentín, J D Humphrey
Jan 11, 2012·Mathematical Biosciences and Engineering : MBE·Panagiotes A VoltairasLambros K Michalis
Nov 8, 2013·Annals of Biomedical Engineering·C BelliniJ D Humphrey
Feb 18, 2014·Biomechanics and Modeling in Mechanobiology·Ruoya WangLuke P Brewster
Nov 7, 2012·Journal of the Mechanical Behavior of Biomedical Materials·Michel R LabrosseCarsten J Beller
Jun 16, 2012·Journal of Biomechanics·A AgianniotisN Stergiopulos
Jun 20, 2012·Mechanics Research Communications·A Valentín, G A Holzapfel
Jul 29, 2011·Forensic Science International : Synergy·Lukas HornySvatava Konvickova
Dec 20, 2011·Mechanics of Materials : an International Journal·Igor Karšaj, Jay D Humphrey
Jan 11, 2011·International Journal of Engineering Science·I KaršajJ D Humphrey
Mar 10, 2016·Theoretical and Computational Fluid Dynamics·Vittoria FlaminiBoyce E Griffith
Sep 27, 2014·Journal of Theoretical Biology·D E MoultonR Chirat
Dec 17, 2008·Journal of Biomechanics·J D HumphreyR L Gleason
May 29, 2013·International Journal for Numerical Methods in Biomedical Engineering·A ValentínG A Holzapfel
Jul 22, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Nan QiXiaoyu Luo
Oct 27, 2015·Annals of Biomedical Engineering·M CillaM A Martínez
Jan 31, 2015·Biomechanics and Modeling in Mechanobiology·M SmoljkićN Famaey
Jan 7, 2014·Journal of Biomechanics·Claire RobertsonSteven C George
Mar 19, 2013·Journal of the Mechanical Behavior of Biomedical Materials·S RoccabiancaJ D Humphrey
Nov 22, 2011·Journal of the Mechanical Behavior of Biomedical Materials·Lukas HornySvatava Konvickova
May 10, 2011·Journal of Biomechanics·L A González-TorresJ M García-Aznar
Dec 23, 2011·Journal of Biomechanics·J D Humphrey, G A Holzapfel
Oct 17, 2014·Surgical Endoscopy·James D CezoMark E Rentschler
Apr 29, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Boran ZhouTarek Shazly
Apr 4, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Ali HemmasizadehKurosh Darvish
Feb 11, 2015·Journal of Theoretical Biology·Rebecca M Vandiver
Aug 3, 2010·Journal of Vascular Surgery·Carsten J BellerMichel R Labrosse
Jul 13, 2013·Journal of the Mechanical Behavior of Biomedical Materials·Tobias Waffenschmidt, Andreas Menzel
Jan 2, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Chen-Ket ChaiFrank P T Baaijens
Oct 9, 2015·International Journal for Numerical Methods in Biomedical Engineering·A MontaninoM Angelillo
Jul 11, 2016·Biomechanics and Modeling in Mechanobiology·Lei WangXiaoyu Luo
Dec 14, 2011·Computer Methods in Biomechanics and Biomedical Engineering·H SchmidM Itskov

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