Origin of Bolivian Quechua Amerindians: their relationship with other American Indians and Asians according to HLA genes

European Journal of Medical Genetics
Jorge Martinez-LasoAntonio Arnaiz-Villena

Abstract

The Incas were Quechua-speaking people who settled down near Cuzco (Peru). They had an empire ranging from Ecuador to Chile, when Spanish conquerors seized their kingdom around 1532 AD. Nowadays, Quechua-speaking people inhabits Colombia, Ecuador, Bolivia, Peru and Argentina; however, Quechua language was imposed by both Incas and Spaniards to many non-Quechua speaking communities. We have taken a sample of Quechuan Bolivian blood donors from La Paz (Titicaca Lake region) where Inca-Quechuas themselves believed that came from. This group was compared with 6892 individuals from 68 different world populations regarding HLA/DNA allele frequencies distribution. Genetic distances, dendrograms and correspondence analyses were carried out in order to establish relationships among populations. The main conclusions are: (1) DRB1 and -DQB1 haplotypes shared with Asians are found in Quechuas and are not observed in other (Mesoamerican) Amerindians. (2) Aymara-speaking people from the same Titicaca Lake (La Paz) area shows close genetic distances with Quechuas in one dimension results (genetic distances); however, their HLA gene frequency distribution differs according to Neighbor-Joining (NJ) trees and correspondence analysis (multidimens...Continue Reading

References

Jul 1, 1992·Human Immunology·X GaoS W Serjeantson
Jul 1, 1992·Tissue Antigens·X GaoS W Serjeantson
Jan 1, 1992·Immunogenetics·X GaoS W Serjeantson
Dec 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·M Nei
Jan 1, 1983·Journal of Molecular Evolution·M NeiY Tateno
Aug 1, 1995·Human Immunology·A Arnaiz-VillenaJ Martinez-Laso
Aug 9, 1996·Science·F E Leon-SA Ariza-C
Sep 1, 1996·American Journal of Physical Anthropology·M BannaiK Omoto
Aug 1, 1997·Tissue Antigens·B MunkhbatK Tsuji
Feb 12, 1998·Tissue Antigens·H IzaabelA Sanchez-Mazas
Mar 7, 1998·Human Genetics·B GrahovacJ Klein
Jun 20, 1998·Immunogenetics·A Olivo-DíazA Arnaiz-Villena
Feb 11, 1999·American Journal of Human Genetics·F R SantosR J Mitchell
Mar 3, 1999·American Journal of Human Genetics·T M KarafetM F Hammer
Apr 15, 1999·Tissue Antigens·A Arnaiz-VillenaJ Martínez-Laso
Nov 7, 1999·Tissue Antigens·J Bruges-ArmasA Arnaiz-Villena
Apr 25, 2000·Tissue Antigens·E Gómez-CasadoA Arnaiz-Villena
Feb 13, 2001·Tissue Antigens·R de PabloJ Martín
Mar 22, 2001·Tissue Antigens·A Arnaiz-VillenaJ Martínez-Laso
Mar 6, 2003·Human Biology·Mara H HutzFrancisco M Salzano
Jun 26, 2003·Tissue Antigens·E Gómez-CasadoA Arnaiz-Villena
Sep 5, 2003·Nature·Rolando González-JoséSilvina Van Der Molen
Aug 9, 1996·Science·P Parham

❮ Previous
Next ❯

Citations

Dec 17, 2008·The Journal of Physiology·Lucrecia PostigoStacy Zamudio
Nov 25, 2006·Molecular Immunology·Roberto AlegreAntonio Arnaiz-Villena
Jun 6, 2009·International Journal of Immunogenetics·A Arnaiz-VillenaJ Moscoso
Aug 13, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Fernando SalvadorIsrael Molina
Sep 26, 2014·Immunological Investigations·Antonio Arnaiz-VillenaDiego Rey
Apr 10, 2015·Journal of Lower Genital Tract Disease·Daron G FerrisAnneliese Lilienthal
Dec 30, 2010·Genetic Testing and Molecular Biomarkers·Antonio Arnaiz-VillenaGilberto Vargas-Alarcón
Dec 10, 2014·Drug Metabolism and Drug Interactions·Carolina Céspedes-GarroUNKNOWN CEIBA Consortium of the Ibero-American Network of Pharmacogenetics and Pharmacogenomics RIBEF
Oct 7, 2010·Immunological Investigations·Gilberto Vargas-AlarcónAntonio Arnaiz-Villena
Apr 13, 2010·Immunological Investigations·Gilberto Vargas-AlarcónAntonio Arnaiz-Villena
May 15, 2013·Molecular Biology Reports·Diego ReyAntonio Arnaiz-Villena
Aug 23, 2005·Molecular Immunology·Gilberto Vargas-AlarcónAntonio Arnaiz-Villena

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.