Origin of deficits in the flicker electroretinogram of the cone system in X-linked retinoschisis as derived from response nonlinearities

Journal of the Optical Society of America. A, Optics, Image Science, and Vision
Kenneth R AlexanderGerald A Fishman

Abstract

The aim of this study was to identify the origin of a high-frequency attenuation in the flicker electroretinogram (ERG) of patients with X-linked retinoschisis (XLRS) through an analysis of nonlinearities in the ERG response. The ERGs of six patients with XLRS and six age-similar control subjects were recorded in response to stimuli that consisted of pairs of sinusoids that had varying temporal frequencies and that differed by either 8 or 16 Hz. Compared with the control subjects, the patients with XLRS showed a significant reduction in the amplitude of the difference frequency to high-frequency stimuli that paralleled the high-frequency attenuation of their ERG response fundamental. This result indicates that a response attenuation at an initial linear filter, most likely photoreceptoral, was a major determinant of the reduced ERG amplitude of the XLRS patients at high temporal frequencies. Additional analyses of nonlinearities in the ERG responses provided evidence of a postreceptoral component to the flicker ERG deficits of the XLRS patients, as well.

References

Feb 1, 1992·Optometry and Vision Science : Official Publication of the American Academy of Optometry·J V OdomF C Riemslag
Feb 1, 1992·Optometry and Vision Science : Official Publication of the American Academy of Optometry·S A BurnsM R Kreitz
Jan 1, 1990·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·U KellnerA Wessing
Oct 1, 1987·Journal of the Optical Society of America. A, Optics and Image Science·W H SwansonJ Pokorny
Apr 1, 1987·Archives of Ophthalmology·N S PeacheyM G Brigell
Aug 1, 1972·Archives of Ophthalmology·W A Manschot
Jan 1, 1968·Archives of Ophthalmology·M YanoffL E Zimmerman
Jun 1, 1993·Journal of the Optical Society of America. A, Optics and Image Science·Y ChangM R Kreitz
Jul 1, 1993·The British Journal of Ophthalmology·U Kellner, M H Foerster
Oct 1, 1995·Vision Research·D C Hood, D G Birch
Mar 1, 1996·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·R A Bush, P A Sieving
Mar 1, 1996·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·S A Burns, A E Elsner
Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·B B LeeJ Pokorny
Aug 18, 2000·Documenta Ophthalmologica. Advances in Ophthalmology·K BradshawD Trump

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Citations

Oct 9, 2002·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·James A ArmitageAlgis J Vingrys
Jul 3, 2016·Documenta Ophthalmologica. Advances in Ophthalmology·J Jason McAnanyEdwin M Stone

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