Origin of fasciculations in root lesions

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Mamede de Carvalho, Michael Swash

Abstract

Fasciculations are occasionally observed in root lesions, but their site of origin is uncertain. We studied the origin of fasciculations (FPs) in consecutive patients with mild chronic L5 root lesions, excluding peripheral nerve lesion. We used a novel technique of double-EMG needle recording, in which each needle was placed in the territory of separate motor units. With this technique the observation of synchronous FPs implies an origin proximal to distal axonal branching. FPs were found in 13% of 84 consecutive patients with mild chronic L5 root lesions. In 25% they were synchronous in different motor units. We suggest that in mild L5 root lesions most FPs have an origin at distal branches but some FPs originate proximally (25%), possibly at the site of nerve compression. The proximal site of compression and more distal sites may both initiate fasciculation potentials in proximal root lesions.

References

Mar 1, 1979·Annals of Neurology·A Wettstein
Dec 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·M JankoK Gersak
Mar 1, 1984·Journal of the Neurological Sciences·G Roth
Dec 1, 1982·Annals of Neurology·G Roth
Nov 1, 1994·Muscle & Nerve·R B Layzer
Apr 10, 1957·Acta Physiologica Scandinavica·F BUCHTHALF ROSENFALCK
Jan 30, 1959·Acta Physiologica Scandinavica·F BUCHTHALP ROSENFALCK
Jan 30, 2008·Neurology·Bert U KleineMachiel J Zwarts
May 14, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Kerry R Mills
Aug 2, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·J L Bowden, P A McNulty
Aug 9, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Bert U KleineDick F Stegeman
Feb 19, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Mamede de Carvalho, Michael Swash
Oct 23, 2013·JAMA Neurology·Mamede de Carvalho, Michael Swash
Aug 26, 2014·The Spine Journal : Official Journal of the North American Spine Society·Richard Bostelmann, Hans Jakob Steiger

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Citations

Sep 18, 2016·The Journal of Physiological Sciences : JPS·Mamede de Carvalho, Michael Swash
May 12, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Mamede de CarvalhoMichael Swash

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