PMID: 5914694Feb 1, 1966

Origin of granules in polymorphonuclear leukocytes. Two types derived from opposite faces of the Golgi complex in developing granulocytes

The Journal of Cell Biology
D F Bainton, Marilyn G Farquhar

Abstract

The origin, nature, and distribution of polymorphonuclear leukocyte (PMN) granules were investigated by examining developing granulocytes from normal rabbit bone marrow which had been fixed in glutaraldehyde and postfixed in OsO(4). Two distinct types of granules, azurophil and specific, were distinguished on the basis of their differences in size, density, and time and mode of origin. Both types are produced by the Golgi complex, but they are formed at different stages of maturation and originate from different faces of the Golgi complex. Azurophil granules are larger ( approximately 800 mmicro) and more dense. They are formed only during the progranulocyte stage and arise from the proximal or concave face of the Golgi complex by budding and subsequent aggregation of vacuoles with a dense core. Smaller ( approximately 500 mmicro), less dense specific granules are formed during the myelocyte stage; they arise from the distal or convex face of the Golgi complex by pinching-off and confluence of vesicles which have a finely granular content. Only azurophil granules are found in progranulocytes, but in mature PMN relatively few (10 to 20%) azurophils are seen and most (80 to 90%) of the granules present are of the specific type. T...Continue Reading

References

Jul 1, 1965·The Journal of Cell Biology·Marilyn G Farquhar, G E Palade
Jul 25, 1958·The Journal of Biophysical and Biochemical Cytology·M L WATSON
Nov 1, 1960·Stain Technology·K C RICHARDSONE H FINKE
Jan 1, 1961·Zeitschrift für Zellforschung und mikroskopische Anatomie·E SCHARRER, S BROWN
Apr 1, 1963·The Journal of Cell Biology·Hilton H Mollenhauer, W G Whaley
Jan 31, 1964·Zeitschrift für Zellforschung und mikroskopische Anatomie·S R Wellings, J R PHILP
Oct 1, 1964·The Journal of Experimental Medicine·D ZUCKER-FRANKLIN, J G Hirsch
Oct 1, 1964·The Journal of Cell Biology·J D Jamieson, G E Palade
Jan 1, 1965·The Journal of Experimental Medicine·Martha E Fedorko, S I MORSE
Sep 17, 1964·Zeitschrift für Zellforschung und mikroskopische Anatomie·E W DANIELS
Jul 1, 1965·The American Journal of Anatomy·D S FRIEND, M J MURRAY
Dec 1, 1961·The Journal of Biophysical and Biochemical Cytology·M J Karnovsky
Dec 1, 1961·Experimental Neurology·G D PAPPAS, D P PURPURA

Citations

Jul 1, 1969·The American Journal of Anatomy·R Cornell, H A Padykula
Nov 1, 1969·The American Journal of Anatomy·L H Larkin, C J Flickinger
Nov 1, 1970·The American Journal of Anatomy·F Campbell
Jun 1, 1977·The American Journal of Anatomy·P P BruynS Michelson
Apr 1, 1970·The Anatomical Record·R L Wood
Dec 1, 1967·Arthritis and Rheumatism·L M Luckenbill, A S Cohen
May 18, 1973·Zeitschrift für Zellforschung und mikroskopische Anatomie·I L ChenH S Lin
Jan 1, 1968·Zeitschrift für Zellforschung und mikroskopische Anatomie·I Carr
Jul 1, 1971·Zeitschrift für Zellforschung und mikroskopische Anatomie·G A Ackerman
Jan 1, 1967·Zeitschrift für Zellforschung und mikroskopische Anatomie·I Carr
Jan 1, 1967·Zeitschrift für Zellforschung und mikroskopische Anatomie·I Carr
Jan 1, 1971·Zeitschrift für Zellforschung und mikroskopische Anatomie·S Y FengL H Khairallah
Aug 1, 1975·Biochemical Genetics·C K Grieshaber, H A Hoffman
Sep 1, 1975·The Histochemical Journal·J StuartT R Lee
Jan 1, 1981·The Histochemical Journal·M J KarnovskyM L Karnovsky
Oct 1, 1969·Blut·R B Scott, Y Abul-Fadl
Dec 15, 1977·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·F C LudwigW L Bostick
Jan 1, 1978·Agents and Actions·M BaggioliniM E Feigenson
Aug 15, 1967·Experientia·H J Huser, C M Webb
Jan 1, 1974·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·T Fukuda
Jan 1, 1984·Developmental and Comparative Immunology·J Quesada, B Agulleiro
Jan 1, 1983·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·R Chibber, A G Castle
Nov 14, 2003·Microbes and Infection·Mikkel Faurschou, Niels Borregaard
Feb 1, 1981·The Journal of Pediatrics·R T ParmleyH Findley
Aug 5, 1967·Nature·C A Squier, J P Waterhouse
Oct 3, 2002·Nature Reviews. Molecular Cell Biology·Brad J Marsh, Kathryn E Howell
Oct 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·A E MirskyV C Littau
Feb 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·S ClarkeS Gordon
Nov 1, 1966·The Journal of Cell Biology·R E Smith, Marilyn G Farquhar
Dec 1, 1966·The Journal of Cell Biology·J W Combs
Sep 1, 1967·The Journal of Cell Biology·P M Seeman, G E Palade
Jun 1, 1968·The Journal of Cell Biology·G E Palade, R R Bruns
Oct 1, 1968·The Journal of Cell Biology·B Bowers, E D Korn
Feb 1, 1970·The Journal of Cell Biology·D M Phillips
Mar 1, 1970·The Journal of Cell Biology·J M Strum, M J Karnovsky
Apr 1, 1970·The Journal of Cell Biology·D F Bainton, Marilyn G Farquhar
Sep 1, 1970·The Journal of Cell Biology·G E Wise, C J Flickinger
Aug 1, 1971·The Journal of Cell Biology·B A NicholsMarilyn G Farquhar
May 1, 1972·The Journal of Cell Biology·J D CastleG E Palade
Feb 1, 1973·The Journal of Cell Biology·S J Abrahams, E Holtzman
Apr 1, 1973·The Journal of Cell Biology·R W Young
Nov 1, 1976·The Journal of Cell Biology·D Sandoz, E Biosvieux-Ulrich
Sep 1, 1984·The Journal of Cell Biology·A A Rogalski, S J Singer
Feb 1, 1969·The Journal of Experimental Medicine·C E McCallM Finland
Mar 1, 1970·The Journal of Experimental Medicine·M BaggioliniJ F Heremans
Oct 1, 1970·The Journal of Experimental Medicine·R van FurthMartha E Fedorko
Oct 1, 1971·The Journal of Experimental Medicine·D F BaintonMarilyn G Farquhar
Sep 22, 2006·Antioxidants & Redox Signaling·Henk-Jan van ManenCees Otto
Jan 1, 1969·The British Journal of Dermatology·J C Poole
Aug 1, 1971·British Journal of Haematology·J J Theron, R C Mekel
Feb 1, 1971·British Journal of Haematology·A I Freeman, L J Journey
May 1, 1975·British Journal of Haematology·R S WeingerM Baker
Jan 1, 1975·British Journal of Haematology·D F Bainton
Jan 1, 1983·British Journal of Haematology·K P SchofieldJ Stuart
Aug 1, 1972·Acta Pathologica Japonica·K FukushiK Yoshida
Jul 1, 1980·Acta Pathologica Japonica·O TakeokaT Ashihara
Feb 1, 1969·The Journal of protozoology·K Vickerman
May 1, 1972·The Journal of protozoology·H M Jensen, S R Wellings
Oct 14, 1969·Annals of the New York Academy of Sciences·B F Sloat, J M Allen
Oct 14, 1969·Annals of the New York Academy of Sciences·R E Smith
Jan 1, 1994·Veterinary Clinical Pathology·A. R. Kiehl, C. A. Schiller
Feb 1, 1975·Annals of the Rheumatic Diseases·K T Rajan
Jul 1, 1978·Journal of Clinical Pathology·J T WozniakJ Stuart
Jan 1, 1983·Journal of Clinical Immunology·M FerrariniC E Grossi
Jul 27, 2012·Annual Review of Cell and Developmental Biology·Marilyn G Farquhar
Dec 1, 1973·Journal of Cellular Physiology·T M DexterB I Lord
Feb 1, 1977·The Anatomical Record·M E BentfeldD F Bainton
Oct 1, 1971·Journal of Morphology·A L Allenspach, J D Berlin
Mar 1, 1969·Journal of Morphology·J R RubyR G Skalko
Aug 28, 2015·Proceedings of the National Academy of Sciences of the United States of America·Benjamin D EngelWolfgang Baumeister
Jan 1, 1969·The Anatomical Record·C J Flickinger
Dec 1, 1967·Journal of Morphology·F Campbell
Jan 1, 1976·American Journal of Hematology·M C TerritoM J Cline
Nov 1, 1973·The Journal of Experimental Zoology·R I McDonald
Dec 1, 1967·The Journal of Experimental Zoology·C B Kimmel
Jan 1, 1991·Annals of the New York Academy of Sciences·P DaviesR A Mumford
Jan 1, 1969·Tissue & Cell·M J Berridge, J L Oschman
Mar 1, 1971·Journal of Ultrastructure Research·G Devauchelle
Nov 1, 1969·Journal of Ultrastructure Research·A Dumont
May 1, 1967·Journal of Ultrastructure Research·J D Pickett-Heaps
Nov 1, 1973·Journal of Ultrastructure Research·M Dauwalder, W G Whaley
May 1, 1974·Journal of Ultrastructure Research·E J WenkJ A Rhodin
Aug 1, 1967·Journal of Ultrastructure Research·M Baca, L Zamboni
Aug 30, 1967·Journal of Ultrastructure Research·B L Scott
Jan 1, 1969·Experimental Cell Research·P Farnes, B E Barker
Feb 1, 1989·Experimental Cell Research·J CullyA Hasilik
Jun 15, 1986·Toxicology and Applied Pharmacology·L A DethloffG E Hook
Feb 1, 1986·Experimental and Molecular Pathology·R T ParmleyL A Boxer
Aug 1, 1975·Experimental Parasitology·C E Bennett, L T Threadgold
Sep 1, 1972·Current Problems in Pediatrics·P G Quie
Jun 1, 1985·Anatomia, histologia, embryologia·C P Maala, J F Cummings
Feb 1, 1988·The American Journal of Anatomy·C FittschenJ C Williams
Jun 1, 1983·British Journal of Haematology·K P SchofieldJ Stuart
Jul 1, 1985·The American Journal of Anatomy·C MoralesL Hermo
Jan 1, 1981·Journal of Supramolecular Structure and Cellular Biochemistry·W A Shannon, D M Zellmer
Apr 1, 1982·The American Journal of Anatomy·X M TangY Clermont
Feb 1, 1987·British Journal of Haematology·K Bendix-Hansen
Jan 1, 1981·Developmental and Comparative Immunology·A Zapata
May 15, 2015·Cell and Tissue Research·Dina AmihaiIlan Hammel
Jul 6, 2014·Biophysical Journal·Joshua Zimmerberg, Paul S Blank
Aug 21, 2007·Molecular Immunology·Kiran Ambatipudi, Elizabeth M Deane
Feb 15, 1996·Biochimica Et Biophysica Acta·L M Henderson, J B Chappel
Aug 26, 2016·Immunological Reviews·Jack B Cowland, Niels Borregaard
Feb 1, 1983·Journal of Periodontology·F A DeRenzis, S Y Chen
Mar 1, 1986·Veterinary Pathology·N R Facklam, G J Kociba
Jun 22, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·D H YangF Murata
Dec 1, 1977·European Journal of Immunology·D S LinthicumE L Cooper
Feb 1, 1971·Cancer·M E Kadin, K G Bensch
Jun 30, 2005·Molecular & Cellular Proteomics : MCP·George LominadzeKenneth R McLeish
Jul 31, 2013·American Journal of Clinical Pathology·Michael Van NessPaul Holland
Jan 1, 1979·Journal of Dairy Science·M J PaapeR E Pearson
Apr 1, 1969·Journal of Cellular Physiology·H LipkeJ Petrali
Dec 1, 2017·Cell and Tissue Research·Charles Yin, Bryan Heit
Jan 1, 1991·Veterinary Clinical Pathology·Nemi C. JainJoseph G. Zinkl
Jul 16, 2020·The Journal of Biological Chemistry·Vignesh VenkatakrishnanAnna Karlsson-Bengtsson
Jan 1, 1979·American Journal of Hematology·J Groopman, L Ellman
Jan 1, 1992·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·I B Lamster, M J Novak
May 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kol A ZaremberJohn I Gallin
Apr 1, 1970·Blut·K Kriesten, H Enbergs
Jan 1, 1968·Pathologia Veterinaria·H J Nafstad, I Nafstad
Aug 1, 1984·Hoppe-Seyler's Zeitschrift für physiologische Chemie·D K GuptaA Hasilik
Nov 12, 2017·Cell and Tissue Research·Débora Moreira AlvarengaGustavo Batista Menezes
May 12, 2018·Journal of Leukocyte Biology·Rossana C N Melo, Peter F Weller
Jul 1, 1985·Veterinary Pathology·N R Facklam, G J Kociba
Aug 1, 1973·Acta Pathologica Et Microbiologica Scandinavica. Section B: Microbiology and Immunology·C TagessonL Edebo
Jan 1, 1972·Scandinavian Journal of Haematology·D CatovskyJ Robinson
Jan 1, 1969·Zeitschrift für Zellforschung und mikroskopische Anatomie·A Balázs
Jan 1, 1980·Journal of Morphology·M Samuel CannonChristy Tompkins
Jan 1, 1971·Zeitschrift für Zellforschung und mikroskopische Anatomie·G A Ackerman
Sep 1, 1975·Journal of Mathematical Biology·S I Rubinow, J L Lebowitz
Jan 1, 1970·Histochemie. Histochemistry. Histochimie·J Doerr-Schott
Mar 9, 2019·JACC. Basic to Translational Science·Heather L TeagueNehal N Mehta
Aug 28, 2020·Molecular Aspects of Medicine·Julian UgonottiMorten Thaysen-Andersen

Related Concepts

Bone Marrow Cells
Cytoplasmic Granules
Golgi Apparatus
Leukocytes
Microscopy
Electron Microscopy

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.