Jul 3, 2015

Origin of microglia: current concepts and past controversies

Cold Spring Harbor Perspectives in Biology
Florent Ginhoux, Marco Prinz

Abstract

Microglia are the resident macrophages of the central nervous system (CNS), which sit in close proximity to neural structures and are intimately involved in brain homeostasis. The microglial population also plays fundamental roles during neuronal expansion and differentiation, as well as in the perinatal establishment of synaptic circuits. Any change in the normal brain environment results in microglial activation, which can be detrimental if not appropriately regulated. Aberrant microglial function has been linked to the development of several neurological and psychiatric diseases. However, microglia also possess potent immunoregulatory and regenerative capacities, making them attractive targets for therapeutic manipulation. Such rationale manipulations will, however, require in-depth knowledge of their origins and the molecular mechanisms underlying their homeostasis. Here, we discuss the latest advances in our understanding of the origin, differentiation, and homeostasis of microglial cells and their myelomonocytic relatives in the CNS.

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Mentioned in this Paper

Brain
Environment
Fetishism (Psychiatric)
Cell Differentiation Process
Cell Growth
Mental Disorders
Neuronal
Microglial
Psychiatry Specialty
Manipulation (Therapeutics)

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