Origin of serum hepatitis B virus in acute exacerbation: comparison with HBV in the liver and from other exacerbation

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Chun-Jen LiuDing-Shinn Chen

Abstract

Acute exacerbation (AE) of chronic hepatitis B is usually preceded by reemergence or increase of hepatitis B virus (HBV) in the serum. To investigate the origin of the reemergence or increase, we compared the identity of the serum viral genome to that in the liver and in previous AE by full-length sequencing. The full-length viral genome and extent of quasispecies were obtained from serum and liver biopsy specimens at the same time from 9 subjects with hepatitis B exacerbation (group I). Composition of viral quasispecies was compared by the genetic diversity and the average number of nucleotide substitutions within and between different viral sources. Another 2 patients with repeated AEs (group II) were also enrolled, and their serial serum alanine aminotransferase, HBV DNA levels and full-length sequences were determined. In all group I patients, serum viral genome was identical to that in the liver. The genetic diversity and the average number of nucleotide difference were also comparable between serum and liver tissue. In 2 group II patients, the viral variant that emerged after previous AE was not identical to that caused by the subsequent AE. Dominant viral strains for serial AEs in a single patient did not show a sequenti...Continue Reading

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Citations

Jan 20, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chun-Jen LiuDing-Shinn Chen
Nov 6, 2015·International Journal of Molecular Sciences·Sha LiYibin Feng
Dec 26, 2015·International Journal of Molecular Sciences·Wei-Lun TsaiJin-Shiung Cheng
Apr 26, 2007·Journal of Medical Virology·I-Chin WuTing-Tsung Chang
Oct 15, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Huei-Ru ChengChun-Jen Liu
Aug 25, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Natalia M Araujo
Feb 8, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Chee-Kin Hui, George K K Lau

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